Seeds grant vision to your team.
Placing a seed in your spell's path after you have cast it gives you the best chance of having a seed in the proper spot.
Zyra is a great ambusher - look for opportunities to set a trap of seeds in brush, then lure enemies in.
Lead your enemy when targeting with Noxious Blast to ensure the hit.
Use Twin Fang on poisoned stationary targets like monsters and units stunned by her Petrifying Gaze for maximum damage.
The Zyra Cassiopeia synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Cassiopeia, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Zyra sees a very large drop in her KDA (ratio of kills and assists to deaths) when paired with Cassiopeia. His KDA decreased from NaN to NaN. This decrease shows that Cassiopeia helps Zyra perform not as well in ranked League of Legends matches. Yet, the small difference demonstrates that this performance change is not very impactful.
When Zyra tries to synergize with Cassiopeia, she gets a marginal improvement in her full damage dealt. This change could indicate that Cassiopeia supports by providing protection for her to dish out more damage or that her support also helps increase the game's duration. Similarly, when Zyra is played together with Cassiopeia on the same side, he usually scores many fewer killing sprees compared to when she plays alone. This is contrasting evidence that she is worse when playing with Cassiopeia.
Moreover, when Zyra plays with Cassiopeia on the same side, she usually receives a little more damage than when she fights alone. Getting dealt more damage may mean that Cassiopeia does a poor job of covering Zyra in team fights.
There is no top champion pairing for Zyra that will 100% of the time be her best synergy. However, Cassiopeia is a good ally for Zyra. By being on the same side as Zyra, she raises their win rate by 2.2% to 54.8%. This proves that there is a good bond between Zyra and Cassiopeia that results in them performing better together than without each other.
Cassiopeia has a greater difficulty than Zyra. That means Zyra players need to be very careful when finding Cassiopeia teammates to play with, as they will need a greater level of skill to work well with you.
Fighting alongside, you will likely see an overall large increase in your team’s capacity to deal magic damage. When paired, these champs can deal quite a lot of AP type damage.
In contrast, by bringing Zyra and Cassiopeia together, you probably will not be granting your other allies much AD. Plan to bring other champions on your team that offsets this hole in this pairing's abilities.
Regardless of the ability of your Cassiopeia ally, you need to focus on maximizing your gold income, outlasting your enemies, and clearing objectives. If you do this, you will do well anyway.
To learn all of the intricacies of Zyra to pair well with Cassiopeia during both the lane and mid / late game phases of LoL games, you should keep reading to master additional lessons on this champion pairing. If you listen to the build and tips presented above, you will increase your win rate by a lot.
The most important finished items to include in your Zyra and Cassiopeia synergy build include Zhonya's Hourglass, Zaz'Zak's Realmspike, and Liandry's Torment. When Zyra included at least these three finished items in her build, she performed much better when fighting alongside Cassiopeia than with many other common item sets. In fact, Zyra had an average winrate of 54.8% when synergizing her build and playstyle to Cassiopeia with this build.
To have the greatest likelihood of coming out on top against your oponents, Zyra players should take the Arcane Comet, Manaflow Band, Transcendence, Scorch, Relentless Hunter, and Taste of Blood runes from the Sorcery and Domination rune sets. Out of all the runes players used for this champion pairing, this set of runes resulted in the greatest win rate. Moreover, these runes gave a 54.8% winrate overall.
If you would like to see Zyra with Cassiopeia cooperations tips and stats for a a specific skill level, feel free to choose one from the selection menu provided above. At first, the statistics and guides given are calculated using all matches played with both champs.