Time Warp is an effective way to enable allies to finish off enemies, or escape from a losing battle.
Chronoshift is a powerful deterrent to attacking your carries, but casting Chronoshift too early in a fight can cause the enemy to switch targets too soon, making it less effective.
You can combine the use of Time Bomb and Rewind to place two Time Bombs on a target quickly. Placing the second bomb will detonate the first and stun all nearby enemies.
Lead your enemy when targeting with Noxious Blast to ensure the hit.
Use Twin Fang on poisoned stationary targets like monsters and units stunned by her Petrifying Gaze for maximum damage.
The Zilean Cassiopeia synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Cassiopeia, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Zilean sees a very large drop in his KDA (ratio of kills and assists to deaths) when paired with Cassiopeia. His KDA went down from NaN to NaN. This drop shows that Cassiopeia helps Zilean perform poorer in competitive League of Legends matches. Yet, the small difference demonstrates that this performance change is only marginal.
When Zilean plays on the same team as Cassiopeia, he observes a noticable drop in his full damage dealt. This may indicate that Cassiopeia does not provide cover for him to dish out more damage or that her presence on the team also helps extend the round's duration. Similarly, when Zilean is played together with Cassiopeia on the same side, he usually scores many fewer killing sprees than when he plays on his own. This is contrasting evidence that he is worse when playing synergisticly with Cassiopeia.
Additionally, when Zilean plays with Cassiopeia on the same team, he on average receives less damage than when he fights alone. Taking not as much damage could mean that Cassiopeia does a decent job of covering Zilean during team fights.
There is no one best champion pairing for Zilean that will no matter what be his best ally. Yet, Cassiopeia is a decent ally for Zilean. By locking into the same team as Zilean, she improves their win rate by 2.6% to 53.3%. This proves that there is a good synergy between Zilean and Cassiopeia that allows them to perform stronger together than without each other.
Cassiopeia has a much greater difficulty compared to Zilean. That means you should be cautious when finding Cassiopeia allies to fight alongside, as they will have to have a much greater level of skill to be able to play well with you.
Fighting on the same side, Zilean players should expect to witness an overall large increase in your team’s capacity to to do a lot of AP damage. When paired, these two can deal quite a lot of AP type damage.
Although, by aligning Zilean and Cassiopeia together, you may not be providing your other teammates enough attack damage. Make sure to include other champs on your team that fills this relative gap in this pairing's kit.
Regardless of your Cassiopeia ally's skill level, you should focus on increasing your gold income, staying alive by avoiding foolish fights, and clearing objectives. If you follow these simple suggestions, you will do well anyway.
To learn all of the intricacies of Zilean in order to work well with Cassiopeia during both the lane and mid / late game phases of League of Legends, you should continue reading to gather a few extra tricks and insights into this champion pairing. If you use the build and stats shown above, you will increase your win rate by a lot.
The most crucial finished items to include in your Zilean and Cassiopeia synergy build include Shurelya's Battlesong, Solstice Sleigh, and Imperial Mandate. When Zilean incorporated at least these three items in his build, he did significantly better when paired up with Cassiopeia than with many other common builds. In fact, Zilean had an average win rate of 53.3% when playing alongside Cassiopeia with this build.
To have the highest probability of vanquishing your oponents, you should take the Summon Aery, Manaflow Band, Transcendence, Waterwalking, Cheap Shot, and Relentless Hunter runes from the Sorcery and Domination rune sets. Out of all the rune sets players chose for Zilean and Cassiopeia pairings, this blending of runes resulted in the best win rate. Moreover, these runes averaged a 53.3% winrate overall.
By default, tips, statistics, and builds on how to team up Cassiopeia with Zilean are shown for all ranked divisions. If you want to filter the stats and builds to a particular player tier, you can use the selection menu located earlier on the page.