Placing a Living Shadow before using Death Mark can give Zed a safe escape from combat.
Saving energy and spell cooldowns until you use your ultimate will maximize Death Mark's damage.
Quickly double tapping Living Shadow will teleport Zed to his shadow immediately for rapid escapes.
Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
The Zed Karthus synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Karthus, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Zed sees a very large drop in his KDA (ratio of kills and assists to deaths) when paired with Karthus. His KDA worsened from NaN to NaN. This negative change shows that Karthus helps Zed perform not as well in ranked LoL matches. Yet, the small difference proves that this performance change is not very impactful.
When Zed is an ally to Karthus, he observes a small increase in his complete damage dealt. This could demonstrate that Karthus helps provide cover for him to deal more damage or that his participation also helps extend the game's duration. Similarly, when Zed is played alongside Karthus on the same team, he usually scores many fewer killing sprees than when he plays on his own. This is contrasting evidence that he is worse when playing synergisticly with Karthus.
Moreover, when Zed plays with Karthus on the same side, he typically receives a little more damage than when he fights alone. Taking more damage may mean that Karthus does a poor job of protecting Zed in team fights.
There is no universally accepted best synergy for Zed that will always be his #1 teammate. However, Karthus is a very typical teammate for Zed. By playing on the same team as Zed, he drops their win rate by -0.4% to 48.0%. This proves that there is only a small synergy between Zed and Karthus that allows them to perform worse together than without each other.
Karthus has a lower difficulty than Zed. That means Zed players don't need to be careful when finding Karthus teammates to play with, as they will have to have a lower level of skill to be able to cooperate well with you.
Working on the same side, you will likely see an overall large increase in your team’s capacity to deal physical damage. Together, these champs can provide a great amount of sustained physical damage.
In contrast, by bringing Zed and Karthus together, you probably will not be granting your side enough cover. Plan to bring other champions on your team that neutralizes this relative gap in their potential.
Regardless of the ability of your Karthus ally, you should focus on maximizing your gold income, outlasting your enemies, and taking down objectives. If you heed this simple advice, you will do well, regardless.
To truly master Zed to synergize with Karthus during both the laning and mid / late game phases of LoL games, you should keep reading to pick up a few extra tricks and insights into this champion pairing. If you listen to the build and stats displayed here, you will increase your win rate significantly.
The top finished items to have in your Zed and Karthus synergy build include Serylda's Grudge, Axiom Arc, and Profane Hydra. When Zed incorporated at least these three items in his build, he performed much better when paired up with Karthus than with many other common builds. In fact, Zed boasted an average winrate of 48.0% when playing alongside Karthus with this build.
To have the greatest chance of crushing your oponents, you should equip the Electrocute, Taste of Blood, Eyeball Collection, Ultimate Hunter, Scorch, and Transcendence runes from the Domination and Sorcery rune sets. Of all the rune builds players picked for Zed and Karthus pairings, this sequence of runes resulted in the highest win rate. In fact, these runes averaged a 48.0% winrate overall.
If you would like to get Zed and Karthus collaboration tips and stats for a a distinct division, please choose one from the selection menu displayed above. By default, the stats and guides given are calculated using every game completed with these champions.