Transfusion instantly deals damage to the enemy before healing Vladimir, making it one of the best last hitting tools in the game.
Cast Hemoplague where it will afflict the most units.
Sanguine Pool pops incoming missiles, so it can be used to dodge disables.
Don't go in first to a large teamfight. Wait for your teammates to initiate.
Tumble has many uses, but it cannot pass over walls.
Condemn can be used to both pin targets to walls to ensure a kill, or to escape a pursuer.
The Vladimir Vayne synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Vayne, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Vladimir sees a large worsening in his KDA (ratio of kills and assists to deaths) when paired with Vayne. His KDA went down from NaN to NaN. This decrease shows that Vayne helps Vladimir perform worse in ranked League rounds. Yet, the small difference shows that this performance change is only marginal.
When Vladimir is paired with Vayne, he gets a little increase in his complete damage dealt. This may demonstrate that Vayne provides cover for him to deal more damage or that her presence on the team also helps increase the match's duration. Similarly, when Vladimir is played with Vayne on the same side, he usually scores many fewer killing sprees compared to when he plays on his own. This is contrasting evidence that he is worse when playing with Vayne.
Moreover, when Vladimir plays with Vayne on the same side, he often takes a little less damage than when he plays alone. Taking not as much damage may indicate that Vayne does a decent job of covering Vladimir during team fights.
There is no top ally for Vladimir that will 100% of the time be his ideal ally. However, Vayne is a good teammate for Vladimir. By being on the same team as Vladimir, she increases their win rate by 2.2% to 52.2%. This signals that there is a good bond between Vladimir and Vayne that results in them performing better together than without each other.
Vayne has a greater difficulty than Vladimir. That means you need to be cautious when finding Vayne comrades to go into battle on the same side as, as they will require a greater level of skill to play well with you.
Working alongside, you should expect to observe an overall large increase in your team’s capacity to deal physical damage. Combined, these champs can tear through the other team with a lot of physcial damage.
Conversely, by bringing Vladimir and Vayne together, you will not be granting your other allies a great deal of utility. Make sure to include other champs on your team that fills this relative hole in this pairing's kit.
Regardless of the ability of your Vayne teammate, you need to focus on maximizing your income, warding to avoid ambushes, and taking down objectives. If you do this, you will do well anyway.
If you would like to learn all of the intricacies of Vladimir in order to work well with Vayne during both the early game and mid / late game phases of League matches, you should continue reading to gather a few extra tips and tricks for this champion pairing. If you listen to the build and suggestions shown above, you will increase your win rate by a lot.
The best items to get in your Vladimir and Vayne synergy build include Riftmaker, Shadowflame, and Liandry's Torment. When Vladimir included at least these three items in his build, he performed a lot better when paired up with Vayne than with most other commonly used item sets. In fact, Vladimir had an average win rate of 52.2% when synergizing his build and playstyle to Vayne with these items in his kit.
To have the highest probability of crushing your oponents, Vladimir players should use the Phase Rush, Nimbus Cloak, Transcendence, Gathering Storm, Conditioning, and Overgrowth runes from the Sorcery and Resolve rune sets. Out of all the rune sets players chose for this champion pairing, this set of runes resulted in the highest win rate. In fact, these runes gave a 52.2% winrate overall.
By default, tips, stats, and builds on how to team up Vayne with Vladimir are given for all ranked divisions combined. To narrow the stats and builds to a specific skill level, you may use the selection menu located earlier in the counter matchup guide.