Don't go in first to a large teamfight. Wait for your teammates to initiate.
Tumble has many uses, but it cannot pass over walls.
Condemn can be used to both pin targets to walls to ensure a kill, or to escape a pursuer.
Infinite Duress (R)'s distance scales with any Move Speed you gain, even from ally buffs and summoner spells.
Follow your Blood Hunt trails to low health enemy champions.
Jaws of the Beast (Q) will follow enemies who run, dash or teleport if you keep the button held down.
The Vayne Warwick synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Warwick, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Vayne sees a very large drop in her KDA (ratio of kills and assists to deaths) when paired with Warwick. His KDA decreased from NaN to NaN. This negative change shows that Warwick helps Vayne perform worse in ranked LoL rounds. Yet, the small difference proves that this performance change is not very impactful.
When Vayne is paired with Warwick, she sees a little decrease in her full damage output. This change could signal that Warwick doesn't help protection for her to dish out more damage or that his support also helps extend the game's duration. Similarly, when Vayne is played together with Warwick on the same side, he usually scores many fewer killing sprees compared to when she plays on his own. This is contrasting evidence that she is worse when playing alongside Warwick.
Additionally, when Vayne plays with Warwick on the same side, she usually receives a little less damage than when she fights alone. Receiving not as much damage could mean that Warwick does a decent job of protecting Vayne in teamfights.
There is no one best synergy for Vayne that will always be her best synergy. However, Warwick is a very typical ally for Vayne. By locking into the same team as Vayne, he lowers their win rate by -1.0% to 49.3%. This proves that there is not really a strong bond between Vayne and Warwick that allows them to perform not as well together than without each other.
Warwick has a much lower diffuclty than Vayne. That means you don't need to be careful when finding Warwick teammates to fight alongside, as they will need a much lower level of skill to play well with you.
Working alongside, Vayne players should expect to see an overall large increase in your team’s ability to deal physical damage. Together, these champs can tear through the other team with a lot of physcial damage.
In contrast, by grouping Vayne and Warwick together, you may not be providing your other allies very much magic damage. Plan to have other champs on your team that offsets this relative disparity in their playstyle.
Regardless of your Warwick ally's ability, you need to focus on increasing your income, outlasting your enemies, and clearing objectives. If you heed this simple advice, you should do well anyway.
If you would like to learn all of the intricacies of Vayne to pair well with Warwick during both the early game and mid / late game phases of LoL matches, you should continue reading to gather additional tips and tricks for this champion pairing. If you use the build and suggestions presented here, you will increase your win rate significantly.
The ideal finished items to build first in your Vayne and Warwick synergy build include Guardian Angel, Wit's End, and Guinsoo's Rageblade. When Vayne bought at least these three great items in her build, she did significantly better as an ally of Warwick than with most other common builds. In fact, Vayne boasted an average winrate of 49.3% helping carry Warwick with this build.
To have the best likelihood of beating your oponents, you should take the Fleet Footwork, Triumph, Legend: Alacrity, Coup de Grace, Conditioning, and Overgrowth runes from the Precision and Resolve rune sets. Out of all the runes we have analyed for Vayne and Warwick pairings, this blending of runes resulted in the best win rate. Notably, these runes provided a 49.3% winrate overall.
By default, tips, stats, and builds on how to synergize Warwick with Vayne are shown for all skill levels combined. If you would like to narrow the statistics and builds to a specific division, you can use the selection menu earlier in the counter matchup guide.