Don't go in first to a large teamfight. Wait for your teammates to initiate.
Tumble has many uses, but it cannot pass over walls.
Condemn can be used to both pin targets to walls to ensure a kill, or to escape a pursuer.
Contaminate has a large range; apply as many stacks of Deadly Venom as possible before using it.
You can catch up to an enemy out of attack range with Venom Cask.
Twitch's Attack Speed is among the highest in the game; try purchasing items with on-hit effects such as Black Cleaver or Wit's End.
The Vayne Twitch synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Twitch, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Vayne sees a very large drop in her KDA (ratio of kills and assists to deaths) when paired with Twitch. His KDA went down from NaN to NaN. This fall shows that Twitch helps Vayne perform worse in ranked League of Legends matches. Yet, the small difference demonstrates that this performance change is only marginal.
When Vayne is paired with Twitch, she sees a marginal improvement in her total damage output. This difference could indicate that Twitch helps provide cover for her to deal more damage or that his allyship also helps extend the round's duration. Similarly, when Vayne is played with Twitch on the same side, he usually scores many fewer killing sprees than when she plays alone. This is contrasting evidence that she is worse when playing with Twitch.
Additionally, when Vayne plays with Twitch on the same side, she usually takes a little more damage than when she fights alone. Receiving more damage may mean that Twitch does a poor job of covering Vayne during teamfights.
There is no universally accepted best synergy for Vayne that will no matter what be her best teammate. Yet, overall, Twitch is a not very good teammate for Vayne. By locking into the same side as Vayne, he lowers their win rate by -1.3% to 49.0%. This shows that there is a harmful bond between Vayne and Twitch that allows them to perform not as well together than without each other.
Twitch has a lower difficulty than Vayne. That means Vayne players don't need to be careful when arranging Twitch allies to go into battle on the same side as, as they will need a lower level of skill to do well with you.
Working together, Vayne players should see an overall large increase in your team’s capability to destroy wih physical damage. Together, these champions should be able to take down targets with auto-attacks and other AD damage abilities.
Conversely, by grouping Vayne and Twitch together, you will not be providing your other teammates very much cover. We recommend you bring other champions on your team that nullifies this disparity in this pairing's abilities.
Regardless of your Twitch ally's skill level, you need to focus on increasing your gold income, outlasting your enemies, and clearing objectives. If you heed this simple advice, you should do well, regardless.
If you would like to truly master Vayne in order to work well with Twitch during both the lane and mid / late game phases of League of Legends rounds, you should keep reading to learn a few extra tricks and insights into this champion pairing. If you use the build and tips displayed above, you will increase your win rate significantly.
The most crucial finished items to prioritize in your Vayne and Twitch synergy build consist of Guardian Angel, Guinsoo's Rageblade, and Blade of The Ruined King. When Vayne combined at least these three pieces in her build, she did a lot better when paired up with Twitch than with most other common builds. In fact, Vayne boasted an average winrate of 49.0% when playing alongside Twitch with these items in her kit.
To have the best chance of beating your oponents, Vayne players should take the Lethal Tempo, Triumph, Legend: Alacrity, Coup de Grace, Conditioning, and Overgrowth runes from the Precision and Resolve rune sets. Out of all the rune sets players used for this champion pairing, this combination of runes yielded the highest win rate. Moreover, these runes averaged a 49.0% win rate overall.
By default, tips, statistics, and builds on how to team up Twitch with Vayne are given for all ranked divisions combined. To narrow the stats and builds to a distinct skill level, you should use the selection menu located earlier on the page.