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How to Synergize Vayne with Seraphine on the Same TeamVayne is in the s tier of champions

Vayne with Seraphine

How to Win With Vayne and Seraphine Paired TogetherVayne is in the b tier of champions
MarksmanAssassin
MageSupport

How to Synergize Vayne and Seraphine

based on 6,573 Vayne with Seraphine pairs
Win Rate
48.7 %
K/D/A
1.91
Pick Rate
3.2 %

How We Analyze Champion Pairings in LoL

Our servers take in the results of from millions of League matches directly from Riot Games each week. Vayne has fought alongside Seraphine in 6573 recent, competitive games. By amassing so much relevant data directly from the makers of LoL, we have complete confidence that we can produce robust, accurate builds to help Vayne synergize with Seraphine. It is relatively rare for Vayne to play with Seraphine on the same team. This has only taken place in approximately 3.2% of matches with Vayne.

Vayne Seraphine Synergy Summary

Unfortunately, Vayne has done a dismal job of synergizing with Seraphine. Usually, she wins an acceptable 48.7% of the time the champs try and synergize their gameplay. If you want to win more matches as Vayne when playing alongside Seraphine by learning how to better synergize your gameplay with her, then dig into the complete build (with items, runes, summoner spells, and skills) below!

Best Vayne vs Seraphine Counter Build

Items

Starter Items

Time Target
CullHealth Potion

Early Items

~5 Mins
DaggerVampiric Scepter

Core Vayne Items

~22 Mins
Wit's EndTerminusKraken Slayer

Optional Items

BloodthirsterTrinity ForceRunaan's HurricaneVoltaic Cyclosword

Summoner Spells

summonerflash summoner spell D
summonerhaste summoner spell F

Skill Order

First skill for Vayne to level upw
>
Second ability for Vayne to level upq
>
Last skill for Vayne to max oute

Runes

PrecisionLethal TempoTriumphLegend: AlacrityCoup de Grace
ResolveConditioningOvergrowth
Attack SpeedAdaptive ForceArmor
Vayne's passive ability p
Vayne's q ability q
Vayne's w ability w
Vayne's e ability e
Vayne's ultimate ability r
1
Q
2
W
3
E
4
W
5
W
6
R
7
W
8
Q
9
W
10
Q
11
R
12
Q
13
Q
14
E
15
E
16
R

Guide to Synergizing Vayne and Seraphine

Tips for Playing as Vayne with Seraphine

Don't go in first to a large teamfight. Wait for your teammates to initiate.

Tumble has many uses, but it cannot pass over walls.

Condemn can be used to both pin targets to walls to ensure a kill, or to escape a pursuer.

Vayne Seraphine Synergy Stats

Vayne Image
Win Rate
48.7 %
VS
Win Rate
51.3 %
Seraphine Image
7.3
< Kills >
7.4
6.6
< Deaths >
6.4
5.3
< Assists >
5.5
1.7
< Killing Sprees >
1.73
159
< Minions Killed >
163
0.17
< Dragons Killed >
0.19
0.47
< Inhibitors >
0.49
15,023
< Physical Damage >
14,953
1,470
< Magic Damage >
1,533
4,509
< True Damage >
4,426
21,002
< Damage Dealt >
20,913
21,549
< Damage Taken >
21,594
11,958
< Gold Earned >
12,107
2.25
< Towers >
2.26
0.05
< Baron Takedowns >
0.06
5,935
< Total Healing >
6,006
13,022
< Experience >
12,904
17
< Vision Score >
18
9
< Wards Placed >
9
67
< Time Dealing CC >
69

How to Play with Seraphine as Vayne in LoL

The Vayne Seraphine synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Seraphine, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.

Overall, Vayne sees a large worsening in her KDA (ratio of kills and assists to deaths) when paired with Seraphine. His KDA fell from NaN to NaN. This fall shows that Seraphine helps Vayne perform poorer in competitive League of Legends rounds. Yet, the small difference proves that this performance change is not very impactful.

When Vayne is an ally to Seraphine, she gets a small increase in her complete damage dealt. This could demonstrate that Seraphine provides cover for her to dish out more damage or that her allyship also helps increase the game's duration. Similarly, when Vayne is played together with Seraphine on the same side, he usually scores many fewer killing sprees than when she plays alone. This is contrasting evidence that she is worse when playing with Seraphine.

Moreover, when Vayne plays with Seraphine on the same team, she usually receives a little less damage than when she plays alone. Taking not as much damage could mean that Seraphine does a decent job of protecting Vayne during teamfights.

Synergies between Vayne and Seraphine

Damage Types Compared

Vayne
Seraphine
Physical Damage
Magic Damage
True Damage

Champion Playstyles Contrasted

Vayne
Seraphine

Is Vayne better when played alongside Seraphine?

There is no one best ally for Vayne that will always be her top ally. Yet, Seraphine is a below average companion for Vayne. By locking into the same team as Vayne, she lowers their win rate by -1.6% to 48.7%. This demonstrates that there is a negative strategic relationship between Vayne and Seraphine that results in them performing worse together than without each other.

Seraphine has a much lower diffuclty than Vayne. That means you don't need to be very careful when enlisting Seraphine teammates to fight alongside, as they will have to have a much lower level of skill to be able to play well with you.

Playing together, Vayne players should expect to see an overall large increase in your team’s capability to provide a lot of utility for your team. When paired, these champions may be able to carry with the power of their abilities.

Although, by aligning Vayne and Seraphine together, you will not be granting your side very much AP. We recommend you bring other champions on your team that nullifies this hole in their kit.

Regardless of the skill of your Seraphine ally, you should focus on maximizing your gold income, warding to avoid ambushes, and clearing objectives. If you follow these simple suggestions, you will do well anyway.

Additional Information for Vayne Players

How We Calculated Our Vayne Seraphine Synergy Build and Stats

For this guide on pairing Vayne and Seraphine, we analyzed 6,573 ranked and recent League of Legends matches. We perform advanced data cleaning and statistical methods to guarantee that our team synergy stats are accurate and reliable. You can be confident that our recommended build to pair Vayne with Seraphine comes from actual data and is not the fabrication of some random LoL player, as some other sites provide. You can use the filters at the top of the page to view your division's most relevant stats and build.

Other Useful Resources

Further Insights to Win with this Champion Pairing

If you would like to truly master Vayne to work well with Seraphine during both the early game and mid / late game phases of LoL matches, you should keep reading to gather some more tricks and insights into this champion pairing. If you pay attention to the build and stats displayed here, you should increase your win rate by a lot.

The most crucial items to have in your Vayne and Seraphine synergy build include Wit's End, Terminus, and Kraken Slayer. When Vayne combined at least these three pieces in her build, she performed much better as an ally of Seraphine than with most other typical item sets. In fact, Vayne had an average winrate of 48.7% when playing alongside Seraphine with these items in her kit.

To have the greatest chance of crushing your oponents, Vayne players should equip the Lethal Tempo, Triumph, Legend: Alacrity, Coup de Grace, Conditioning, and Overgrowth runes from the Precision and Resolve rune sets. Out of all the runes players chose for Vayne and Seraphine pairings, this mixture of runes yielded the greatest win rate. Notably, these runes gave a 48.7% win rate overall.

By default, tips, statistics, and builds on how to synergize Seraphine with Vayne are shown for all skill levels combined. If you want to narrow the statistics and builds to a distinct rank, you can use the selection menu located earlier on the page.