Don't go in first to a large teamfight. Wait for your teammates to initiate.
Tumble has many uses, but it cannot pass over walls.
Condemn can be used to both pin targets to walls to ensure a kill, or to escape a pursuer.
Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
The Vayne Karthus synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Karthus, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Vayne sees a large worsening in her KDA (ratio of kills and assists to deaths) when paired with Karthus. His KDA worsened from NaN to NaN. This fall shows that Karthus helps Vayne perform worse in ranked League of Legends rounds. Yet, the small difference shows that this performance change is not very impactful.
When Vayne tries to synergize with Karthus, she sees a marginal improvement in her complete damage output. This could demonstrate that Karthus provides cover for her to dish out more damage or that his presence on the team also helps extend the game's duration. Similarly, when Vayne is played alongside Karthus on the same side, he usually scores many fewer killing sprees than when she plays on his own. This is contrasting evidence that she is worse when playing synergisticly with Karthus.
Additionally, when Vayne plays with Karthus on the same team, she on average receives more damage than when she plays alone. Taking more damage may mean that Karthus does a poor job of covering Vayne in team fights.
There is no one best companion for Vayne that will 100% of the time be her #1 teammate. Yet, overall, Karthus is a terrible companion for Vayne. By being on the same side as Vayne, he drops their win rate by -3.9% to 46.4%. This shows that there is an easy to overcome and exploit bond between Vayne and Karthus that allows them to perform worse together than without each other.
Karthus has a lower difficulty than Vayne. That means you don't need to be very careful when enlisting Karthus comrades to fight alongside, as they will have to have a relatively low level of skill to be able to cooperate well with you.
Fighting alongside, you will likely see an overall large increase in your team’s ability to dish out massive AD. Together, these champions can tear through the other team with a lot of physcial damage.
In contrast, by grouping Vayne and Karthus together, you will not be giving your team a great deal of tankyness. Make sure to have other champions on your team that nullifies this relative disparity in their potential.
Regardless of the skill of your Karthus ally, you should focus on increasing your income, outlasting your enemies, and taking down objectives. If you heed this simple advice, you will do well, regardless.
To learn all of the intricacies of Vayne in order to work well with Karthus during both the laning and mid / late game phases of League of Legends rounds, you should keep reading to pick up a few extra tricks and insights into this champion pairing. If you listen to the build and stats displayed here, you will grow your win rate by a lot.
The most crucial items to have in your Vayne and Karthus synergy build include Statikk Shiv, Guinsoo's Rageblade, and Blade of The Ruined King. When Vayne included at least these three great items in her build, she did much better when fighting alongside Karthus than with most other commonly used builds. In fact, Vayne had an average winrate of 46.4% helping carry Karthus with this build.
To have the greatest likelihood of crushing your oponents, you should take the Lethal Tempo, Triumph, Legend: Alacrity, Coup de Grace, Conditioning, and Overgrowth runes from the Precision and Resolve rune sets. Out of all the rune combinations players chose for Vayne and Karthus pairings, this set of runes resulted in the best win rate. In fact, these runes averaged a 46.4% winrate overall.
If you want to see Vayne with Karthus cooperations tips and stats for a an individual player tier, feel free to choose one from the selection menu above. At first, the stats and strategies displayed are computed using all rounds completed with both champions.