Don't go in first to a large teamfight. Wait for your teammates to initiate.
Tumble has many uses, but it cannot pass over walls.
Condemn can be used to both pin targets to walls to ensure a kill, or to escape a pursuer.
Don't be too conservative with Mantra. Gathering Fire is strongest in teamfights, making it easy to recharge Mantra multiple times.
Gathering Fire rewards aggressive play. Look to land abilities and basic attacks on your opponent to lower Mantra's cooldown and stay on the offensive.
When using Focused Resolve, slow your opponents with Inner Flame or speed yourself up with Inspire if you're having trouble sticking to a target.
The Vayne Karma synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Karma, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Vayne sees a large worsening in her KDA (ratio of kills and assists to deaths) when paired with Karma. His KDA went down from NaN to NaN. This decrease shows that Karma helps Vayne perform poorer in competitive League rounds. Yet, the small difference indicates that this performance change is only marginal.
When Vayne tries to synergize with Karma, she observes a little increase in her full damage dealt. This could signal that Karma provides protection for her to deal more damage or that her presence on the team also helps extend the game's duration. Similarly, when Vayne is played together with Karma on the same side, he usually scores many fewer killing sprees than when she plays without Karma. This is contrasting evidence that she is worse when playing with Karma.
Additionally, when Vayne plays with Karma on the same side, she usually takes a little less damage than when she plays alone. Taking not as much damage may indicate that Karma does a decent job of covering Vayne during team fights.
There is no universally accepted best ally for Vayne that will 100% of the time be her best ally. However, overall, Karma is a not very good companion for Vayne. By playing on the same team as Vayne, she drops their win rate by -1.8% to 48.5%. This proves that there is a bad bond between Vayne and Karma that results in them performing not as well together than alone.
Karma has a much lower diffuclty than Vayne. That means Vayne players don't need to be cautious when enlisting Karma teammates to play with, as they will need a much lower level of skill to work well with you.
Working cooperatively, you should expect to witness an overall large increase in your team’s capacity to dish out massive AD. Combined, these champs should be able to take down targets with auto-attacks and other AD damage abilities.
Although, by bringing Vayne and Karma together, you probably will not be providing your other teammates much engage potential. Plan to pick other champs on your team that nullifies this disparity in this pairing's kit.
Regardless of your Karma ally's skill level, you should focus on maximizing your gold income, outlasting your enemies, and taking down objectives. If you do this, you should do well, regardless.
If you would like to truly master Vayne in order to synergize with Karma during both the laning and mid / late game phases of LoL matches, you should keep reading to pick up some more lessons on this champion pairing. If you use the build and suggestions presented above, you will grow your win rate significantly.
The top items to have in your Vayne and Karma synergy build consist of Guardian Angel, Guinsoo's Rageblade, and Terminus. When Vayne incorporated at least these three pieces in her build, she did a lot better as an ally of Karma than with many other common item sets. In fact, Vayne boasted an average win rate of 48.5% when playing alongside Karma with this build.
To have the best chance of annihilating your oponents, you should equip the Fleet Footwork, Triumph, Legend: Alacrity, Coup de Grace, Magical Footwear, and Biscuit Delivery runes from the Precision and Inspiration rune sets. Of all the rune builds we have analyed for this champion pairing, this mix of runes yielded the greatest win rate. In fact, these runes gave a 48.5% win rate overall.
If you would like to view Vayne and Karma collaboration tips and builds for a a particular division rank, feel free to choose one from the selection menu provided above. At first, the stats and tips and suggestions given are calculated using every game played with both champs.