Don't go in first to a large teamfight. Wait for your teammates to initiate.
Tumble has many uses, but it cannot pass over walls.
Condemn can be used to both pin targets to walls to ensure a kill, or to escape a pursuer.
Make sure to buy items that will evolve at least 1 or 2 of your spells.
Work with your teammates to set up your Ultimate and optimize damage with your passive.
Try to catch enemy carries alone to burst them with Icathian Rain.
The Vayne Kai'Sa synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Kai'Sa, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Vayne sees a very large drop in her KDA (ratio of kills and assists to deaths) when paired with Kai'Sa. His KDA worsened from NaN to NaN. This drop shows that Kai'Sa helps Vayne perform not as well in ranked League matches. Yet, the small difference proves that this performance change is only marginal.
When Vayne tries to synergize with Kai'Sa, she observes a small increase in her complete damage dealt. This change may indicate that Kai'Sa supports by providing protection for her to deal more damage or that her presence on the team also helps extend the game's duration. Similarly, when Vayne is played together with Kai'Sa on the same side, he usually scores many fewer killing sprees compared to when she plays alone. This is contrasting evidence that she is worse when playing synergisticly with Kai'Sa.
Additionally, when Vayne plays with Kai'Sa on the same side, she usually takes more damage than when she fights alone. Getting dealt more damage could mean that Kai'Sa does a poor job of covering Vayne during team fights.
There is no ideal champion pairing for Vayne that will no matter what be her ideal teammate. However, Kai'Sa is a terrible teammate for Vayne. By locking into the same team as Vayne, she lowers their win rate by -3.8% to 46.5%. This proves that there is a terrible bond between Vayne and Kai'Sa that allows them to perform not as well together than alone.
Kai'Sa has a lower difficulty than Vayne. That means you don't need to be careful when finding Kai'Sa comrades to go into battle on the same side as, as they will require a relatively low level of skill to be able to do well with you.
Working cooperatively, Vayne players should expect to observe an overall large increase in your team’s capability to deal physical damage. When paired, these champs can provide a great amount of sustained physical damage.
Conversely, by aligning Vayne and Kai'Sa together, you probably will not be providing your other allies enough magical damage output. Plan to include other champions on your team that helps cover this gap in their abilities.
Regardless of your Kai'Sa ally's ability, you should focus on increasing your gold income, warding to avoid ambushes, and taking down objectives. If you heed this simple advice, you should do well, regardless.
If you would like to truly master Vayne to pair well with Kai'Sa during both the lane and mid / late game phases of League of Legends rounds, you should keep reading to gather a few extra tricks and insights into this champion pairing. If you use the build and suggestions displayed here, you will grow your win rate by a lot.
The top items to have in your Vayne and Kai'Sa synergy build include Wit's End, Guinsoo's Rageblade, and Terminus. When Vayne incorporated at least these three great items in her build, she did significantly better as an ally of Kai'Sa than with most other typical item sets. In fact, Vayne boasted an average winrate of 46.5% helping carry Kai'Sa with these items in her kit.
To have the greatest probability of vanquishing your oponents, Vayne players should equip the Lethal Tempo, Triumph, Legend: Alacrity, Coup de Grace, Conditioning, and Overgrowth runes from the Precision and Resolve rune sets. Out of all the rune builds players chose for this champion pairing, this blending of runes resulted in the top win rate. In fact, these runes averaged a 46.5% win rate overall.
If you want to view Vayne and Kai'Sa collaboration tips and stats for a an individual player tier, feel free to choose one from the selection menu above. By default, the statistics and strategies given are computed using all rounds run with both champions.