Don't go in first to a large teamfight. Wait for your teammates to initiate.
Tumble has many uses, but it cannot pass over walls.
Condemn can be used to both pin targets to walls to ensure a kill, or to escape a pursuer.
Lead your enemy when targeting with Noxious Blast to ensure the hit.
Use Twin Fang on poisoned stationary targets like monsters and units stunned by her Petrifying Gaze for maximum damage.
The Vayne Cassiopeia synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Cassiopeia, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Vayne sees a large worsening in her KDA (ratio of kills and assists to deaths) when paired with Cassiopeia. His KDA decreased from NaN to NaN. This negative change shows that Cassiopeia helps Vayne perform not as well in ranked League of Legends games. Yet, the small difference shows that this performance change is not very impactful.
When Vayne is paired with Cassiopeia, she observes a small increase in her complete damage dealt. This may signal that Cassiopeia supports by providing protection for her to deal more damage or that her support also helps increase the round's duration. Similarly, when Vayne is played alongside Cassiopeia on the same side, he usually scores many fewer killing sprees compared to when she plays on his own. This is contrasting evidence that she is worse when playing with Cassiopeia.
Moreover, when Vayne plays with Cassiopeia on the same team, she usually takes a little more damage than when she plays alone. Taking more damage may indicate that Cassiopeia does a poor job of protecting Vayne in teamfights.
There is no one best companion for Vayne that will 100% of the time be her ideal teammate. However, overall, Cassiopeia is a decent ally for Vayne. By locking into the same team as Vayne, she raises their win rate by 1.0% to 51.3%. This demonstrates that there is a good synergy between Vayne and Cassiopeia that allows them to perform at the top of their game together than alone.
Cassiopeia has a greater difficulty than Vayne. That means you need to be very careful when arranging Cassiopeia teammates to play with, as they will need a greater level of skill to fight well with you.
Playing cooperatively, Vayne players should observe an overall large increase in your team’s ability to dish out massive AD. Together, these champs should be able to take down targets with auto-attacks and other AD damage abilities.
In contrast, by aligning Vayne and Cassiopeia together, you probably will not be providing your side very much engage. Plan to have other champs on your team that fills this relative gap in this pairing's abilities.
Regardless of your Cassiopeia ally's ability, you need to focus on maximizing your income, outlasting your enemies, and clearing objectives. If you heed this simple advice, you will do well, regardless.
To truly master Vayne to synergize with Cassiopeia during both the lane and mid / late game phases of League of Legends games, you should keep reading to pick up a few extra tips and tricks for this champion pairing. If you pay attention to the build and stats presented here, you should grow your win rate by a lot.
The ideal finished items to prioritize in your Vayne and Cassiopeia synergy build include Wit's End, Guinsoo's Rageblade, and Terminus. When Vayne incorporated at least these three great items in her build, she performed much better as an ally of Cassiopeia than with many other common item sets. In fact, Vayne boasted an average win rate of 51.3% when playing alongside Cassiopeia with these items in her kit.
To have the highest probability of defeating your oponents, Vayne players should take the Lethal Tempo, Triumph, Legend: Alacrity, Coup de Grace, Conditioning, and Overgrowth runes from the Precision and Resolve rune sets. Of all the rune builds we have analyed for this champion pairing, this combination of runes resulted in the highest win rate. Notably, these runes provided a 51.3% win rate overall.
By default, tips, stats, and builds on how to team up Cassiopeia with Vayne are presented for all skill levels, merged. If you would like to scope the statistics and builds to a particular rank, you may use the selection menu located above.