Don't go in first to a large teamfight. Wait for your teammates to initiate.
Tumble has many uses, but it cannot pass over walls.
Condemn can be used to both pin targets to walls to ensure a kill, or to escape a pursuer.
Fire 90 Caliber Net away from the opponent to close the gap or hop over walls.
Avoid using Ace in the Hole in large team melees as it might be blocked by the wrong target.
Make use of her Yordle Snap Traps by placing them pre-emptively to ensure that you'll have one off of cooldown during combat.
The Vayne Caitlyn synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Caitlyn, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Vayne sees a very large drop in her KDA (ratio of kills and assists to deaths) when paired with Caitlyn. His KDA worsened from NaN to NaN. This drop shows that Caitlyn helps Vayne perform poorer in ranked League games. Yet, the small difference shows that this performance change is only marginal.
When Vayne is an ally to Caitlyn, she observes a sizeable uptick in her complete damage dealt. This change may demonstrate that Caitlyn supports by providing cover for her to deal more damage or that her presence on the team also helps extend the round's duration. Similarly, when Vayne is played with Caitlyn on the same team, he usually scores many fewer killing sprees than when she plays on his own. This is contrasting evidence that she is worse when playing alongside Caitlyn.
Moreover, when Vayne plays with Caitlyn on the same side, she often receives more damage than when she fights alone. Getting dealt more damage may mean that Caitlyn does a poor job of covering Vayne in team fights.
There is no one best synergy for Vayne that will no matter what be her ideal teammate. However, Caitlyn is a not very good ally for Vayne. By locking into the same team as Vayne, she decreases their win rate by -2.7% to 47.6%. This clearly indicates that there is a bad bond between Vayne and Caitlyn that allows them to perform worse together than without each other.
Caitlyn has a lower difficulty than Vayne. That means you don't need to be cautious when enlisting Caitlyn comrades to play with, as they will have to have a relatively low level of skill to play well with you.
Fighting on the same side, you should see an overall large increase in your team’s ability to dish out massive AD. When paired, these champions should be able to take down targets with auto-attacks and other AD damage abilities.
Although, by grouping Vayne and Caitlyn together, you may not be providing your side much magical damage output. Make sure to have other champions on your team that nullifies this gap in their capabilities.
Regardless of your Caitlyn ally's skill level, you should focus on increasing your income, outlasting your enemies, and clearing objectives. If you follow these simple suggestions, you should do well, regardless.
To learn all of the intricacies of Vayne in order to work well with Caitlyn during both the lane and mid / late game phases of League matches, you should keep reading to pick up a few extra lessons on this champion pairing. If you listen to the build and tips presented here, you should increase your win rate significantly.
The top finished items to build first in your Vayne and Caitlyn synergy build include Guinsoo's Rageblade, Blade of The Ruined King, and Jak'Sho, The Protean. When Vayne used at least these three great items in her build, she performed much better as an ally of Caitlyn than with many other common item sets. In fact, Vayne boasted an average win rate of 47.6% when synergizing her build and playstyle to Caitlyn with this build.
To have the best chance of crushing your oponents, Vayne players should take the Lethal Tempo, Triumph, Legend: Alacrity, Coup de Grace, Conditioning, and Overgrowth runes from the Precision and Resolve rune sets. Out of all the rune sets players picked for this champion pairing, this combination of runes yielded the best win rate. Notably, these runes gave a 47.6% winrate overall.
If you would like to see Vayne with Caitlyn collaboration tips and stats for a a particular division rank, feel free to choose one from the selection menu shown above. By default, the statistics and tips and suggestions shown are calculated using every match with data with these champions.