Contaminate has a large range; apply as many stacks of Deadly Venom as possible before using it.
You can catch up to an enemy out of attack range with Venom Cask.
Twitch's Attack Speed is among the highest in the game; try purchasing items with on-hit effects such as Black Cleaver or Wit's End.
Time Warp is an effective way to enable allies to finish off enemies, or escape from a losing battle.
Chronoshift is a powerful deterrent to attacking your carries, but casting Chronoshift too early in a fight can cause the enemy to switch targets too soon, making it less effective.
You can combine the use of Time Bomb and Rewind to place two Time Bombs on a target quickly. Placing the second bomb will detonate the first and stun all nearby enemies.
The Twitch Zilean synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Zilean, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Twitch sees a very large drop in his KDA (ratio of kills and assists to deaths) when paired with Zilean. His KDA worsened from NaN to NaN. This worsening shows that Zilean helps Twitch perform worse in competitive League matches. Yet, the small difference indicates that this performance change is not very impactful.
When Twitch is an ally to Zilean, he sees a barely noticable drop in his total damage dealt. This change may demonstrate that Zilean does not provide cover for him to deal more damage or that his allyship also helps extend the game's duration. Similarly, when Twitch is played alongside Zilean on the same team, he usually scores many fewer killing sprees than when he plays on his own. This is contrasting evidence that he is worse when playing alongside Zilean.
Moreover, when Twitch plays with Zilean on the same side, he typically receives a little more damage than when he plays alone. Receiving more damage could indicate that Zilean does a poor job of protecting Twitch during team fights.
There is no top ally for Twitch that will always be his best ally. Yet, Zilean is a good companion for Twitch. By playing on the same team as Twitch, he increases their win rate by 1.0% to 51.0%. This proves that there is pretty good bond between Twitch and Zilean that results in them performing stronger together than without each other.
Zilean has a lower difficulty than Twitch. That means you don't need to be cautious when enlisting Zilean teammates to fight alongside, as they will need a lower level of skill to be able to cooperate well with you.
Playing on the same side, you should witness an overall large increase in your team’s capability to dish out massive AD. Together, these champs should be able to take down targets with auto-attacks and other AD damage abilities.
Conversely, by grouping Twitch and Zilean together, you may not be providing your team enough engage. Plan to include other champions on your team that fills this hole in this pairing's playstyle.
Regardless of your Zilean ally's skill level, you should focus on increasing your gold income, warding to avoid ambushes, and taking down objectives. If you heed this simple advice, you should do well anyway.
If you would like to learn all of the intricacies of Twitch to pair well with Zilean during both the lane and mid / late game phases of LoL rounds, you should continue reading to learn additional tips and tricks for this champion pairing. If you listen to the build and tips presented here, you will increase your win rate by a lot.
The best finished items to build first in your Twitch and Zilean synergy build include Rabadon's Deathcap, Nashor's Tooth, and Shadowflame. When Twitch incorporated at least these three items in his build, he did much better as an ally of Zilean than with many other typical builds. In fact, Twitch had an average win rate of 51.0% when synergizing his build and playstyle to Zilean with this build.
To have the best likelihood of coming out on top against your oponents, you should use the Lethal Tempo, Presence of Mind, Legend: Alacrity, Coup de Grace, Taste of Blood, and Treasure Hunter runes from the Precision and Domination rune sets. Of all the runes players chose for Twitch and Zilean pairings, this mix of runes yielded the highest win rate. Moreover, these runes averaged a 51.0% winrate overall.
By default, tips, stats, and builds on how to synergize Zilean with Twitch are shown for all ranked divisions. If you want to narrow the statistics and builds to a specific skill level, you can use the selection menu earlier in the counter matchup guide.