Contaminate has a large range; apply as many stacks of Deadly Venom as possible before using it.
You can catch up to an enemy out of attack range with Venom Cask.
Twitch's Attack Speed is among the highest in the game; try purchasing items with on-hit effects such as Black Cleaver or Wit's End.
Don't go in first to a large teamfight. Wait for your teammates to initiate.
Tumble has many uses, but it cannot pass over walls.
Condemn can be used to both pin targets to walls to ensure a kill, or to escape a pursuer.
The Twitch Vayne synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Vayne, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Twitch sees a very large drop in his KDA (ratio of kills and assists to deaths) when paired with Vayne. His KDA fell from NaN to NaN. This drop shows that Vayne helps Twitch perform not as well in ranked League games. Yet, the small difference demonstrates that this performance change is not very impactful.
When Twitch tries to synergize with Vayne, he observes a little decrease in his complete damage output. This difference may signal that Vayne does not support by providing protection for him to deal more damage or that her allyship also helps extend the game's duration. Similarly, when Twitch is played alongside Vayne on the same team, he usually scores many fewer killing sprees compared to when he plays alone. This is contrasting evidence that he is worse when playing synergisticly with Vayne.
Moreover, when Twitch plays with Vayne on the same team, he usually receives a little more damage than when he fights alone. Getting dealt more damage could indicate that Vayne does a poor job of covering Twitch in team fights.
There is no universally accepted best synergy for Twitch that will 100% of the time be his #1 teammate. Yet, overall, Vayne is a very typical ally for Twitch. By being on the same side as Twitch, she decreases their win rate by -1.0% to 49.0%. This clearly indicates that there is only a small bond between Twitch and Vayne that allows them to perform worse together than alone.
Vayne has a greater difficulty than Twitch. That means Twitch players need to be cautious when arranging Vayne comrades to play with, as they will have to have a greater level of skill to cooperate well with you.
When playing alongside, Twitch players should expect to observe an overall large increase in your team’s capacity to destroy wih physical damage. When paired, these two can tear through the other team with a lot of physcial damage.
Although, by grouping Twitch and Vayne together, you probably will not be providing your other allies a great deal of tankyness. Plan to bring other champs on your team that neutralizes this gap in this pairing's potential.
Regardless of the ability of your Vayne teammate, you should focus on maximizing your gold income, staying alive by avoiding foolish fights, and taking down objectives. If you do this, you will do well, regardless.
If you would like to learn all of the intricacies of Twitch to pair well with Vayne during both the early game and mid / late game phases of League of Legends rounds, you should continue reading to pick up additional lessons on this champion pairing. If you pay attention to the build and stats displayed above, you should increase your win rate significantly.
The ideal finished items to get in your Twitch and Vayne synergy build include Rabadon's Deathcap, Banshee's Veil, and Nashor's Tooth. When Twitch incorporated at least these three great items in his build, he performed a lot better when fighting alongside Vayne than with many other typical item sets. In fact, Twitch had an average win rate of 49.0% helping carry Vayne with these items in his kit.
To have the greatest likelihood of defeating your oponents, you should use the Lethal Tempo, Presence of Mind, Legend: Alacrity, Coup de Grace, Taste of Blood, and Treasure Hunter runes from the Precision and Domination rune sets. Of all the rune builds players used for Twitch and Vayne pairings, this order of runes yielded the greatest win rate. In fact, these runes provided a 49.0% win rate overall.
If you would like to see Twitch with Vayne synergy tips and stats for a a particular skill level, please choose one from the selection menu displayed above. By default, the statistics and build suggestions displayed are calculated using all rounds finished with these champions.