Contaminate has a large range; apply as many stacks of Deadly Venom as possible before using it.
You can catch up to an enemy out of attack range with Venom Cask.
Twitch's Attack Speed is among the highest in the game; try purchasing items with on-hit effects such as Black Cleaver or Wit's End.
Try to take advantage of Piercing Arrow's very long range to snipe at enemy champions before a fight or as they're trying to flee.
An early point in Blighted Quiver helps harass enemy champions and get killing blows on minions.
During short range fights it's sometimes best to fire Piercing Arrow quickly, rather than charging it to full power.
The Twitch Varus synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Varus, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Twitch sees a large worsening in his KDA (ratio of kills and assists to deaths) when paired with Varus. His KDA decreased from NaN to NaN. This fall shows that Varus helps Twitch perform not as well in competitive League of Legends matches. Yet, the small difference proves that this performance change is only marginal.
When Twitch tries to synergize with Varus, he sees a marginal improvement in his full damage dealt. This change may indicate that Varus helps provide cover for him to dish out more damage or that his support also helps increase the round's duration. Similarly, when Twitch is played with Varus on the same team, he usually scores many fewer killing sprees compared to when he plays on his own. This is contrasting evidence that he is worse when playing with Varus.
Moreover, when Twitch plays with Varus on the same team, he on average takes a little more damage than when he plays alone. Getting dealt more damage may mean that Varus does a poor job of protecting Twitch during team fights.
There is no one best ally for Twitch that will 100% of the time be his top ally. Yet, Varus is a very bad ally for Twitch. By locking into the same team as Twitch, he lowers their win rate by -4.7% to 45.3%. This demonstrates that there is a very bad strategic relationship between Twitch and Varus that results in them performing not as well together than without each other.
Varus has a much lower diffuclty than Twitch. That means Twitch players don't need to be cautious when finding Varus comrades to go into battle on the same side as, as they will require a much lower level of skill to cooperate well with you.
When playing on the same side, Twitch players will likely witness an overall large increase in your team’s capacity to dish out massive AD. When paired, these champions can tear through the other team with a lot of physcial damage.
Conversely, by pairing Twitch and Varus together, you may not be giving your other allies a great deal of protection for burst damage. Plan to bring other champs on your team that nullifies this hole in this pairing's potential.
Regardless of the skill of your Varus ally, you should focus on increasing your gold income, warding to avoid ambushes, and clearing objectives. If you follow these simple suggestions, you should do well anyway.
If you would like to truly master Twitch to synergize with Varus during both the laning and mid / late game phases of LoL games, you should keep reading to learn additional tips and tricks for this champion pairing. If you mind the build and tips displayed above, you should increase your win rate by a lot.
The most important finished items to get in your Twitch and Varus synergy build include Rabadon's Deathcap, Nashor's Tooth, and Zhonya's Hourglass. When Twitch included at least these three pieces in his build, he performed much better when fighting alongside Varus than with most other common builds. In fact, Twitch had an average winrate of 45.3% helping carry Varus with this build.
To have the highest likelihood of vanquishing your oponents, you should use the Lethal Tempo, Presence of Mind, Legend: Alacrity, Coup de Grace, Taste of Blood, and Treasure Hunter runes from the Precision and Domination rune sets. Out of all the rune sets players chose for Twitch and Varus pairings, this combination of runes yielded the highest win rate. Notably, these runes provided a 45.3% win rate overall.
By default, tips, statistics, and builds on how to team up Varus with Twitch are shown for all ranked divisions combined. If you want to scope the stats and builds to an individual division, you may use the selection menu earlier in the counter matchup guide.