Contaminate has a large range; apply as many stacks of Deadly Venom as possible before using it.
You can catch up to an enemy out of attack range with Venom Cask.
Twitch's Attack Speed is among the highest in the game; try purchasing items with on-hit effects such as Black Cleaver or Wit's End.
To maximize your ultimate's damage use it when there are many spheres on the battlefield.
After you hit an enemy champion with Force of Will follow up with Dark Sphere, they'll be slowed and have a hard time avoiding it.
Get one of your spells to rank 5 as quickly as possible, they gain powerful bonus effects at max rank.
The Twitch Syndra synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Syndra, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Twitch sees a large worsening in his KDA (ratio of kills and assists to deaths) when paired with Syndra. His KDA decreased from NaN to NaN. This worsening shows that Syndra helps Twitch perform poorer in competitive League rounds. Yet, the small difference shows that this performance change is not very impactful.
When Twitch tries to synergize with Syndra, he sees a small increase in his full damage output. This could signal that Syndra supports by providing protection for him to deal more damage or that her support also helps increase the game's duration. Similarly, when Twitch is played together with Syndra on the same side, he usually scores many fewer killing sprees compared to when he plays alone. This is contrasting evidence that he is worse when playing with Syndra.
Moreover, when Twitch plays with Syndra on the same side, he on average takes a little more damage than when he plays alone. Getting dealt more damage may indicate that Syndra does a poor job of covering Twitch during team fights.
There is no universally accepted best ally for Twitch that will always be his top teammate. However, overall, Syndra is a terrible teammate for Twitch. By playing on the same side as Twitch, she decreases their win rate by -3.3% to 46.7%. This shows that there is an easy to overcome and exploit bond between Twitch and Syndra that results in them performing worse together than without each other.
Syndra has a greater difficulty than Twitch. That means Twitch players need to be careful when lining up Syndra teammates to fight alongside, as they will require a greater level of skill to do well with you.
Fighting cooperatively, Twitch players should witness an overall large increase in your team’s ability to to do a lot of AP damage. Combined, these champions can deal quite a lot of AP type damage.
Although, by pairing Twitch and Syndra together, you may not be granting your other allies very much cover. Make sure to pick other champs on your team that fills this relative disparity in this pairing's playstyle.
Regardless of the skill of your Syndra teammate, you need to focus on increasing your gold income, outlasting your enemies, and taking down objectives. If you do this, you will do well, regardless.
To truly master Twitch in order to pair well with Syndra during both the laning and mid / late game phases of League, you should continue reading to pick up a few extra tips and tricks for this champion pairing. If you use the build and suggestions shown here, you will increase your win rate by a lot.
The best finished items to get in your Twitch and Syndra synergy build include Infinity Edge, Runaan's Hurricane, and Terminus. When Twitch used at least these three pieces in his build, he performed a lot better when fighting alongside Syndra than with most other common builds. In fact, Twitch had an average win rate of 46.7% when playing alongside Syndra with this build.
To have the highest likelihood of defeating your oponents, you should use the Lethal Tempo, Presence of Mind, Legend: Alacrity, Coup de Grace, Biscuit Delivery, and Magical Footwear runes from the Precision and Inspiration rune sets. Out of all the rune combinations we have analyed for Twitch and Syndra pairings, this combination of runes resulted in the top win rate. In fact, these runes averaged a 46.7% win rate overall.
By default, tips, statistics, and builds on how to pair Syndra with Twitch are given for every ranked division. To filter the statistics and builds to a distinct player tier, you may use the selection menu located earlier in the counter matchup guide.