Contaminate has a large range; apply as many stacks of Deadly Venom as possible before using it.
You can catch up to an enemy out of attack range with Venom Cask.
Twitch's Attack Speed is among the highest in the game; try purchasing items with on-hit effects such as Black Cleaver or Wit's End.
While laning, try to use Death's Hand's piercing damage to damage opponents from a safe distance.
Vision of Empire is quite difficult to land on its own, look for skirmishes around the map where enemies may be distracted or crowd controlled so you can land it more easily.
If you're having trouble rooting an enemy with Nevermove, try throwing it at opponents when they are near their minions so the explosion surprises them.
Demonic Ascension may make Swain very hard to kill but he's pretty easy to get away from. Try building items that can slow opponents to keep them in range if their mobility is overwhelming.
The Twitch Swain synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Swain, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Twitch sees a large worsening in his KDA (ratio of kills and assists to deaths) when paired with Swain. His KDA went down from NaN to NaN. This decrease shows that Swain helps Twitch perform poorer in competitive League of Legends rounds. Yet, the small difference proves that this performance change is only marginal.
When Twitch is an ally to Swain, he gets a little decrease in his total damage dealt. This difference could indicate that Swain does not help protection for him to dish out more damage or that his support also helps extend the game's duration. Similarly, when Twitch is played alongside Swain on the same team, he usually scores many fewer killing sprees than when he plays on his own. This is contrasting evidence that he is worse when playing alongside Swain.
Moreover, when Twitch plays with Swain on the same team, he on average receives a little more damage than when he plays alone. Receiving more damage may mean that Swain does a poor job of protecting Twitch in teamfights.
There is no top synergy for Twitch that will 100% of the time be his ideal teammate. Yet, Swain is a pretty good companion for Twitch. By being on the same team as Twitch, he improves their win rate by 1.2% to 51.2%. This demonstrates that there is a good bond between Twitch and Swain that results in them performing stronger together than alone.
Swain has a greater difficulty than Twitch. That means you must be cautious when finding Swain allies to go into battle on the same side as, as they will require a greater level of skill to be able to cooperate well with you.
Playing alongside, Twitch players should see an overall large increase in your team’s ability to deal magic damage. Together, these champs can deal quite a lot of AP type damage.
Although, by pairing Twitch and Swain together, you probably will not be granting your other allies much crowd control. We recommend you pick other champions on your team that helps cover this hole in this pairing's abilities.
Regardless of the ability of your Swain teammate, you need to focus on increasing your gold income, warding to avoid ambushes, and clearing objectives. If you do this, you should do well, regardless.
To truly master Twitch to synergize with Swain during both the lane and mid / late game phases of LoL, you should keep reading to gather a few extra tips and tricks for this champion pairing. If you use the build and tips shown above, you should increase your win rate by a lot.
The ideal finished items to have in your Twitch and Swain synergy build consist of Infinity Edge, Blade of The Ruined King, and Terminus. When Twitch bought at least these three pieces in his build, he did much better when fighting alongside Swain than with most other common item sets. In fact, Twitch had an average winrate of 51.2% when synergizing his build and playstyle to Swain with these items in his kit.
To have the best chance of beating your oponents, you should use the Hail of Blades, Taste of Blood, Eyeball Collection, Relentless Hunter, Presence of Mind, and Legend: Alacrity runes from the Domination and Precision rune sets. Out of all the rune sets players used for this team composition, this combo of runes resulted in the greatest win rate. Moreover, these runes gave a 51.2% win rate overall.
By default, tips, statistics, and builds on how to synergize Swain with Twitch are displayed for all ranked divisions combined. To scope the stats and builds to a specific player tier, you can use the selection menu earlier in the counter matchup guide.