Contaminate has a large range; apply as many stacks of Deadly Venom as possible before using it.
You can catch up to an enemy out of attack range with Venom Cask.
Twitch's Attack Speed is among the highest in the game; try purchasing items with on-hit effects such as Black Cleaver or Wit's End.
Spell Flux's short cooldown allows it to be used to spread Flux to many enemies.
Use Overload's passive to optimize for maximum damage or maximum speed.
Ryze can move and cast other spells while Realm Warp is charging without cancelling the portal.
The Twitch Ryze synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Ryze, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Twitch sees a large worsening in his KDA (ratio of kills and assists to deaths) when paired with Ryze. His KDA fell from NaN to NaN. This worsening shows that Ryze helps Twitch perform poorer in competitive League games. Yet, the small difference indicates that this performance change is only marginal.
When Twitch plays on the same team as Ryze, he sees a little drop in his full damage dealt. This change could indicate that Ryze doesn't help cover for him to deal more damage or that his participation also helps increase the game's duration. Similarly, when Twitch is played alongside Ryze on the same side, he usually scores many fewer killing sprees compared to when he plays without Ryze. This is contrasting evidence that he is worse when playing with Ryze.
Moreover, when Twitch plays with Ryze on the same side, he on average takes a little more damage than when he plays alone. Taking more damage could mean that Ryze does a poor job of protecting Twitch during team fights.
There is no perfect synergy for Twitch that will 100% of the time be his top synergy. However, Ryze is a very typical companion for Twitch. By being on the same team as Twitch, he decreases their win rate by -0.4% to 49.6%. This clearly indicates that there is a weak bond between Twitch and Ryze that results in them performing worse together than without each other.
Ryze has a greater difficulty than Twitch. That means you must be careful when finding Ryze teammates to fight alongside, as they will need a greater level of skill to fight well with you.
Playing cooperatively, you should observe an overall large increase in your team’s ability to to do a lot of AP damage. Together, these champs can blast through enemies with magic damage.
Although, by bringing Twitch and Ryze together, you may not be providing your side a lot of engage. Plan to have other champs on your team that neutralizes this relative gap in this pairing's kit.
Regardless of the skill of your Ryze teammate, you need to focus on maximizing your gold income, outlasting your enemies, and clearing objectives. If you heed this simple advice, you should do well, regardless.
If you would like to truly master Twitch to synergize with Ryze during both the lane and mid / late game phases of League of Legends, you should keep reading to learn additional lessons on this champion pairing. If you pay attention to the build and tips presented here, you will increase your win rate by a lot.
The ideal items to build first in your Twitch and Ryze synergy build include Runaan's Hurricane, Blade of The Ruined King, and Kraken Slayer. When Twitch included at least these three pieces in his build, he did a lot better as an ally of Ryze than with many other common builds. In fact, Twitch had an average winrate of 49.6% when playing alongside Ryze with these items in his kit.
To have the best likelihood of beating your oponents, Twitch players should equip the Lethal Tempo, Presence of Mind, Legend: Alacrity, Coup de Grace, Taste of Blood, and Treasure Hunter runes from the Precision and Domination rune sets. Out of all the rune sets players used for Twitch and Ryze pairings, this order of runes resulted in the greatest win rate. Notably, these runes provided a 49.6% winrate overall.
If you would like to see Twitch with Ryze synergy tips and stats for a an individual player tier, feel free to select one from the selection menu above. If viewing for the first time, the stats and tips and suggestions displayed are calculated using all rounds finished with both champions.