Contaminate has a large range; apply as many stacks of Deadly Venom as possible before using it.
You can catch up to an enemy out of attack range with Venom Cask.
Twitch's Attack Speed is among the highest in the game; try purchasing items with on-hit effects such as Black Cleaver or Wit's End.
Keeping tunnels spread out across the map will ensure you have choices when you want to cast Void Rush.
Cast Burrow before travelling around the map to take advantage of the increased Move Speed and the safety provided by Tremor Sense.
Tremor Sense can warn you of enemies closing in, and is particularly useful when entering enemy territory.
The Twitch Rek'Sai synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Rek'Sai, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Twitch sees a very large drop in his KDA (ratio of kills and assists to deaths) when paired with Rek'Sai. His KDA went down from NaN to NaN. This worsening shows that Rek'Sai helps Twitch perform worse in ranked League of Legends rounds. Yet, the small difference proves that this performance change is not very impactful.
When Twitch is paired with Rek'Sai, he sees a small increase in his complete damage dealt. This could signal that Rek'Sai helps provide cover for him to dish out more damage or that his presence on the team also helps increase the round's duration. Similarly, when Twitch is played alongside Rek'Sai on the same team, he usually scores many fewer killing sprees compared to when he plays without Rek'Sai. This is contrasting evidence that he is worse when playing with Rek'Sai.
Additionally, when Twitch plays with Rek'Sai on the same team, he usually takes a little less damage than when he plays alone. Receiving not as much damage may mean that Rek'Sai does a decent job of covering Twitch during teamfights.
There is no ideal champion pairing for Twitch that will always be his top synergy. However, overall, Rek'Sai is a terrible ally for Twitch. By being on the same team as Twitch, he drops their win rate by -6.4% to 43.6%. This proves that there is a terrible bond between Twitch and Rek'Sai that results in them performing not as well together than without each other.
Rek'Sai has a much lower diffuclty than Twitch. That means you don't need to be cautious when lining up Rek'Sai teammates to go into battle on the same side as, as they will have to have a much lower level of skill to be able to fight well with you.
Fighting alongside, you should observe an overall large increase in your team’s capacity to deal physical damage. Combined, these champs can provide a great amount of sustained physical damage.
Conversely, by pairing Twitch and Rek'Sai together, you will not be granting your team enough magical damage output. We recommend you pick other champs on your team that neutralizes this relative hole in their potential.
Regardless of your Rek'Sai ally's ability, you should focus on increasing your gold income, outlasting your enemies, and clearing objectives. If you heed this simple advice, you will do well, regardless.
To truly master Twitch in order to work well with Rek'Sai during both the early game and mid / late game phases of League of Legends games, you should continue reading to learn a few extra tips and tricks for this champion pairing. If you mind the build and stats presented here, you should grow your win rate significantly.
The best finished items to get in your Twitch and Rek'Sai synergy build include Infinity Edge, Runaan's Hurricane, and Blade of The Ruined King. When Twitch combined at least these three great items in his build, he performed significantly better as an ally of Rek'Sai than with many other commonly used builds. In fact, Twitch boasted an average win rate of 43.6% when synergizing his build and playstyle to Rek'Sai with these items in his kit.
To have the best chance of coming out on top against your oponents, you should use the Lethal Tempo, Presence of Mind, Legend: Alacrity, Coup de Grace, Taste of Blood, and Treasure Hunter runes from the Precision and Domination rune sets. Of all the rune combinations players picked for Twitch and Rek'Sai pairings, this order of runes resulted in the best win rate. Notably, these runes provided a 43.6% winrate overall.
By default, tips, statistics, and builds on how to synergize Rek'Sai with Twitch are displayed for every ranked division. To scope the stats and builds to a particular rank, you can use the selection menu earlier in the counter matchup guide.