Contaminate has a large range; apply as many stacks of Deadly Venom as possible before using it.
You can catch up to an enemy out of attack range with Venom Cask.
Twitch's Attack Speed is among the highest in the game; try purchasing items with on-hit effects such as Black Cleaver or Wit's End.
The Tap version of Bone Skewer is much faster and deals additional damage.
A lot of your agressive spells are also your escapes. Make sure you always have a plan to get out of the fight.
Hitting an enemy with the Hold version of Bone Skewer will always pull them the same distance. Use it in melee range to throw targets behind you.
Pyke is very fragile so don't be afraid to temporarily run from a fight. You can regenerate a significant amount of health from Gift of the Drowned Ones when enemies can't see you.
The Twitch Pyke synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Pyke, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Twitch sees a large worsening in his KDA (ratio of kills and assists to deaths) when paired with Pyke. His KDA fell from NaN to NaN. This negative change shows that Pyke helps Twitch perform not as well in ranked League of Legends matches. Yet, the small difference indicates that this performance change is only marginal.
When Twitch is paired with Pyke, he gets a small increase in his total damage output. This may indicate that Pyke helps provide protection for him to dish out more damage or that his support also helps extend the match's duration. Similarly, when Twitch is played with Pyke on the same team, he usually scores many fewer killing sprees compared to when he plays alone. This is contrasting evidence that he is worse when playing with Pyke.
Moreover, when Twitch plays with Pyke on the same side, he usually takes a little more damage than when he fights alone. Getting dealt more damage could mean that Pyke does a poor job of covering Twitch during teamfights.
There is no one best ally for Twitch that will no matter what be his top synergy. Yet, Pyke is a very typical companion for Twitch. By being on the same side as Twitch, he lowers their win rate by -1.0% to 49.0%. This demonstrates that there is not really a strong strategic relationship between Twitch and Pyke that results in them performing not as well together than alone.
Pyke has a greater difficulty than Twitch. That means you must be careful when lining up Pyke teammates to go into battle on the same side as, as they will require a greater level of skill to be able to cooperate well with you.
Working together, Twitch players should observe an overall large increase in your team’s capacity to dish out massive AD. When paired, these two can tear through the other team with a lot of physcial damage.
Although, by pairing Twitch and Pyke together, you will not be providing your other allies much AP. We recommend you bring other champions on your team that neutralizes this hole in this pairing's capabilities.
Regardless of the ability of your Pyke ally, you need to focus on maximizing your gold income, staying alive by avoiding foolish fights, and taking down objectives. If you follow these simple suggestions, you should do well anyway.
To truly master Twitch in order to pair well with Pyke during both the lane and mid / late game phases of League of Legends games, you should keep reading to master additional tips and tricks for this champion pairing. If you use the build and tips presented above, you will grow your win rate significantly.
The most important items to include in your Twitch and Pyke synergy build include Runaan's Hurricane, Wit's End, and Terminus. When Twitch bought at least these three great items in his build, he did a lot better when fighting alongside Pyke than with many other common builds. In fact, Twitch had an average winrate of 49.0% helping carry Pyke with these items in his kit.
To have the highest probability of beating your oponents, Twitch players should equip the Hail of Blades, Taste of Blood, Eyeball Collection, Relentless Hunter, Presence of Mind, and Legend: Alacrity runes from the Domination and Precision rune sets. Of all the rune builds that we analyzed for Twitch and Pyke pairings, this set of runes yielded the best win rate. In fact, these runes gave a 49.0% win rate overall.
By default, tips, statistics, and builds on how to team up Pyke with Twitch are presented for all skill levels, merged. If you would like to filter the statistics and builds to a particular rank, you can use the selection menu earlier in the counter matchup guide.