Contaminate has a large range; apply as many stacks of Deadly Venom as possible before using it.
You can catch up to an enemy out of attack range with Venom Cask.
Twitch's Attack Speed is among the highest in the game; try purchasing items with on-hit effects such as Black Cleaver or Wit's End.
Lissandra's abilities are shorter range than those of many mages. As a result, buying items that offer both ability power and defense, like Zhonya's Hourglass and Banshee's Veil, can be a great choice to help her both survive and deal damage.
Casting Glacial Path and then running in the opposite direction will leave your enemies uncertain which way you will actually go.
You can instantly use your ultimate on yourself by pressing the self cast key and the ultimate key at once (alt+R by default).
The Twitch Lissandra synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Lissandra, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Twitch sees a very large drop in his KDA (ratio of kills and assists to deaths) when paired with Lissandra. His KDA worsened from NaN to NaN. This decrease shows that Lissandra helps Twitch perform poorer in competitive League of Legends rounds. Yet, the small difference demonstrates that this performance change is not very impactful.
When Twitch is paired with Lissandra, he observes a small increase in his complete damage output. This difference could demonstrate that Lissandra supports by providing cover for him to dish out more damage or that her participation also helps extend the game's duration. Similarly, when Twitch is played with Lissandra on the same team, he usually scores many fewer killing sprees compared to when he plays on his own. This is contrasting evidence that he is worse when playing synergisticly with Lissandra.
Moreover, when Twitch plays with Lissandra on the same team, he typically takes a little more damage than when he plays alone. Receiving more damage may mean that Lissandra does a poor job of protecting Twitch during team fights.
There is no one best ally for Twitch that will no matter what be his top ally. Yet, overall, Lissandra is a below average teammate for Twitch. By playing on the same team as Twitch, she drops their win rate by -1.7% to 48.3%. This clearly indicates that there is a bad synergy between Twitch and Lissandra that allows them to perform worse together than without each other.
Lissandra has a lower difficulty than Twitch. That means you don't need to be cautious when arranging Lissandra teammates to play with, as they will have to have a lower level of skill to be able to play well with you.
Playing cooperatively, you should expect to witness an overall large increase in your team’s ability to dish out massive AD. When paired, these champions can provide a great amount of sustained physical damage.
In contrast, by grouping Twitch and Lissandra together, you may not be granting your other allies a lot of engage. Make sure to bring other champs on your team that fills this hole in their potential.
Regardless of the ability of your Lissandra teammate, you need to focus on maximizing your gold income, staying alive by avoiding foolish fights, and clearing objectives. If you follow these simple suggestions, you will do well anyway.
To learn all of the intricacies of Twitch to work well with Lissandra during both the laning and mid / late game phases of League of Legends games, you should continue reading to master a few extra tips and tricks for this champion pairing. If you use the build and suggestions presented above, you will grow your win rate significantly.
The most important items to include in your Twitch and Lissandra synergy build consist of Infinity Edge, Runaan's Hurricane, and Blade of The Ruined King. When Twitch used at least these three finished items in his build, he did significantly better when fighting alongside Lissandra than with most other common item sets. In fact, Twitch boasted an average win rate of 48.3% when synergizing his build and playstyle to Lissandra with these items in his kit.
To have the best chance of crushing your oponents, you should take the Hail of Blades, Taste of Blood, Eyeball Collection, Treasure Hunter, Legend: Alacrity, and Presence of Mind runes from the Domination and Precision rune sets. Of all the rune sets we have analyed for Twitch and Lissandra pairings, this combination of runes resulted in the highest win rate. In fact, these runes averaged a 48.3% winrate overall.
By default, tips, statistics, and builds on how to synergize Lissandra with Twitch are presented for all skill levels combined. If you want to narrow the stats and builds to an individual rank, you may use the selection menu earlier in the counter matchup guide.