Contaminate has a large range; apply as many stacks of Deadly Venom as possible before using it.
You can catch up to an enemy out of attack range with Venom Cask.
Twitch's Attack Speed is among the highest in the game; try purchasing items with on-hit effects such as Black Cleaver or Wit's End.
Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
The Twitch Karthus synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Karthus, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Twitch sees a large worsening in his KDA (ratio of kills and assists to deaths) when paired with Karthus. His KDA worsened from NaN to NaN. This decrease shows that Karthus helps Twitch perform not as well in ranked League games. Yet, the small difference indicates that this performance change is only marginal.
When Twitch is paired with Karthus, he gets a little increase in his total damage dealt. This change may signal that Karthus helps provide cover for him to dish out more damage or that his participation also helps increase the game's duration. Similarly, when Twitch is played with Karthus on the same team, he usually scores many fewer killing sprees compared to when he plays on his own. This is contrasting evidence that he is worse when playing with Karthus.
Moreover, when Twitch plays with Karthus on the same team, he on average takes a little more damage than when he plays alone. Taking more damage may indicate that Karthus does a poor job of protecting Twitch in teamfights.
There is no top companion for Twitch that will 100% of the time be his top teammate. However, Karthus is a below average ally for Twitch. By playing on the same side as Twitch, he drops their win rate by -1.8% to 48.2%. This clearly indicates that there is a bad synergy between Twitch and Karthus that allows them to perform worse together than without each other.
Karthus has a greater difficulty than Twitch. That means you should be careful when arranging Karthus allies to fight alongside, as they will require a greater level of skill to be able to cooperate well with you.
Working on the same side, you should expect to observe an overall large increase in your team’s capability to deal magic damage. Together, these champs can deal quite a lot of AP type damage.
Conversely, by pairing Twitch and Karthus together, you probably will not be granting your side a great deal of cover. We recommend you pick other champions on your team that offsets this disparity in their potential.
Regardless of your Karthus ally's ability, you should focus on increasing your income, staying alive by avoiding foolish fights, and clearing objectives. If you follow these simple suggestions, you will do well, regardless.
If you would like to learn all of the intricacies of Twitch in order to pair well with Karthus during both the lane and mid / late game phases of League, you should continue reading to learn additional tips and tricks for this champion pairing. If you mind the build and stats displayed above, you will increase your win rate significantly.
The most crucial finished items to use in your Twitch and Karthus synergy build include Wit's End, Blade of The Ruined King, and Terminus. When Twitch included at least these three pieces in his build, he did much better as an ally of Karthus than with most other typical item sets. In fact, Twitch boasted an average winrate of 48.2% helping carry Karthus with these items in his kit.
To have the greatest likelihood of defeating your oponents, Twitch players should equip the Hail of Blades, Taste of Blood, Eyeball Collection, Treasure Hunter, Legend: Alacrity, and Presence of Mind runes from the Domination and Precision rune sets. Of all the runes players used for this champion pairing, this composite of runes yielded the highest win rate. In fact, these runes averaged a 48.2% winrate overall.
By default, tips, statistics, and builds on how to synergize Karthus with Twitch are given for all ranked divisions. If you would like to filter the statistics and builds to a distinct skill level, you may use the selection menu earlier in the counter matchup guide.