Contaminate has a large range; apply as many stacks of Deadly Venom as possible before using it.
You can catch up to an enemy out of attack range with Venom Cask.
Twitch's Attack Speed is among the highest in the game; try purchasing items with on-hit effects such as Black Cleaver or Wit's End.
Make sure to buy items that will evolve at least 1 or 2 of your spells.
Work with your teammates to set up your Ultimate and optimize damage with your passive.
Try to catch enemy carries alone to burst them with Icathian Rain.
The Twitch Kai'Sa synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Kai'Sa, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Twitch sees a large worsening in his KDA (ratio of kills and assists to deaths) when paired with Kai'Sa. His KDA decreased from NaN to NaN. This negative change shows that Kai'Sa helps Twitch perform worse in competitive League of Legends rounds. Yet, the small difference demonstrates that this performance change is only marginal.
When Twitch is an ally to Kai'Sa, he gets a small increase in his full damage output. This could signal that Kai'Sa helps provide protection for him to dish out more damage or that her support also helps extend the game's duration. Similarly, when Twitch is played alongside Kai'Sa on the same side, he usually scores many fewer killing sprees compared to when he plays on his own. This is contrasting evidence that he is worse when playing with Kai'Sa.
Moreover, when Twitch plays with Kai'Sa on the same team, he usually receives a little more damage than when he fights alone. Receiving more damage could mean that Kai'Sa does a poor job of protecting Twitch during teamfights.
There is no universally accepted best companion for Twitch that will no matter what be his top ally. Yet, overall, Kai'Sa is a very bad ally for Twitch. By playing on the same side as Twitch, she decreases their win rate by -5.1% to 44.9%. This clearly indicates that there is a very bad bond between Twitch and Kai'Sa that results in them performing not as well together than alone.
Kai'Sa has a lower difficulty than Twitch. That means you don't need to be very careful when finding Kai'Sa allies to play with, as they will need a relatively low level of skill to do well with you.
Fighting together, you should expect to observe an overall large increase in your team’s capability to dish out massive AD. Together, these champions can provide a great amount of sustained physical damage.
Conversely, by pairing Twitch and Kai'Sa together, you probably will not be granting your side enough support. We recommend you bring other champs on your team that neutralizes this gap in this pairing's abilities.
Regardless of your Kai'Sa ally's skill level, you need to focus on maximizing your gold income, staying alive by avoiding foolish fights, and taking down objectives. If you heed this simple advice, you will do well, regardless.
If you would like to truly master Twitch in order to synergize with Kai'Sa during both the lane and mid / late game phases of LoL games, you should continue reading to learn some more lessons on this champion pairing. If you listen to the build and suggestions displayed above, you should increase your win rate by a lot.
The ideal finished items to have in your Twitch and Kai'Sa synergy build include Runaan's Hurricane, Blade of The Ruined King, and Terminus. When Twitch incorporated at least these three finished items in his build, he did significantly better when fighting alongside Kai'Sa than with many other common item sets. In fact, Twitch boasted an average win rate of 44.9% when playing alongside Kai'Sa with these items in his kit.
To have the best chance of beating your oponents, you should use the Lethal Tempo, Presence of Mind, Legend: Alacrity, Coup de Grace, Taste of Blood, and Treasure Hunter runes from the Precision and Domination rune sets. Of all the rune combinations that we analyzed for Twitch and Kai'Sa pairings, this combo of runes yielded the greatest win rate. Notably, these runes averaged a 44.9% winrate overall.
If you would like to see Twitch and Kai'Sa collaboration tips and builds for a a particular division rank, please select one from the selection menu shown above. By default, the stats and tips and suggestions displayed are computed using every round finished with these champs.