Contaminate has a large range; apply as many stacks of Deadly Venom as possible before using it.
You can catch up to an enemy out of attack range with Venom Cask.
Twitch's Attack Speed is among the highest in the game; try purchasing items with on-hit effects such as Black Cleaver or Wit's End.
Fizz's spells scale off Ability Power - consider getting items like Zhonya's Hourglass or Banshee's Veil against teams that have high burst threat - and items like Lich Bane or Rabadon's Deathcap if you think you can survive without the Health.
Since Fizz can move through units, find opportunities in lane to walk through minions and apply Seastone Trident's passive - following it up with the ability's active attack after a few seconds.
Fizz's ultimate ability, Chum the Waters, can be aimed at an enemy or towards the area where you think they'll be going.
The Twitch Fizz synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Fizz, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Twitch sees a large worsening in his KDA (ratio of kills and assists to deaths) when paired with Fizz. His KDA fell from NaN to NaN. This fall shows that Fizz helps Twitch perform worse in competitive League of Legends matches. Yet, the small difference shows that this performance change is only marginal.
When Twitch is paired with Fizz, he observes a little increase in his total damage output. This difference could demonstrate that Fizz provides protection for him to deal more damage or that his presence also helps extend the match's duration. Similarly, when Twitch is played with Fizz on the same team, he usually scores many fewer killing sprees than when he plays without Fizz. This is contrasting evidence that he is worse when playing synergisticly with Fizz.
Moreover, when Twitch plays with Fizz on the same team, he on average receives a little more damage than when he plays alone. Receiving more damage could indicate that Fizz does a poor job of protecting Twitch during teamfights.
There is no universally accepted best champion pairing for Twitch that will no matter what be his #1 teammate. However, Fizz is a good ally for Twitch. By being on the same side as Twitch, he raises their win rate by 2.1% to 52.1%. This shows that there is a good strategic relationship between Twitch and Fizz that results in them performing at the top of their game together than alone.
Fizz has a lower difficulty than Twitch. That means Twitch players don't need to be very careful when lining up Fizz comrades to fight alongside, as they will require a relatively low level of skill to play well with you.
Working cooperatively, Twitch players will likely observe an overall large increase in your team’s ability to deal physical damage. Together, these champs can provide a great amount of sustained physical damage.
Conversely, by aligning Twitch and Fizz together, you will not be providing your side much utility. We recommend you have other champs on your team that neutralizes this hole in their kit.
Regardless of your Fizz ally's ability, you need to focus on increasing your gold income, staying alive by avoiding foolish fights, and taking down objectives. If you do this, you should do well, regardless.
To truly master Twitch to work well with Fizz during both the early game and mid / late game phases of LoL, you should continue reading to learn some more tips and tricks for this champion pairing. If you pay attention to the build and suggestions presented above, you will increase your win rate by a lot.
The most important finished items to have in your Twitch and Fizz synergy build include Infinity Edge, Lord Dominik's Regards, and Runaan's Hurricane. When Twitch bought at least these three items in his build, he did much better as an ally of Fizz than with many other typical item sets. In fact, Twitch had an average winrate of 52.1% helping carry Fizz with this build.
To have the highest probability of vanquishing your oponents, you should equip the Lethal Tempo, Presence of Mind, Legend: Alacrity, Coup de Grace, Taste of Blood, and Ultimate Hunter runes from the Precision and Domination rune sets. Of all the rune sets that we analyzed for this team composition, this set of runes resulted in the highest win rate. Moreover, these runes gave a 52.1% winrate overall.
If you would like to see Twitch with Fizz collaboration tips and builds for a a specific skill level, feel free to choose one from the selection menu shown above. At first, the stats and build suggestions shown are computed using all rounds finished with these champs.