Contaminate has a large range; apply as many stacks of Deadly Venom as possible before using it.
You can catch up to an enemy out of attack range with Venom Cask.
Twitch's Attack Speed is among the highest in the game; try purchasing items with on-hit effects such as Black Cleaver or Wit's End.
Lead your enemy when targeting with Noxious Blast to ensure the hit.
Use Twin Fang on poisoned stationary targets like monsters and units stunned by her Petrifying Gaze for maximum damage.
The Twitch Cassiopeia synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Cassiopeia, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Twitch sees a large worsening in his KDA (ratio of kills and assists to deaths) when paired with Cassiopeia. His KDA worsened from NaN to NaN. This decrease shows that Cassiopeia helps Twitch perform poorer in ranked League of Legends games. Yet, the small difference shows that this performance change is only marginal.
When Twitch is an ally to Cassiopeia, he sees a marginal improvement in his complete damage dealt. This change could indicate that Cassiopeia supports by providing cover for him to deal more damage or that her presence on the team also helps increase the game's duration. Similarly, when Twitch is played with Cassiopeia on the same team, he usually scores many fewer killing sprees than when he plays alone. This is contrasting evidence that he is worse when playing alongside Cassiopeia.
Moreover, when Twitch plays with Cassiopeia on the same team, he usually takes a little more damage than when he fights alone. Taking more damage may mean that Cassiopeia does a poor job of protecting Twitch during teamfights.
There is no universally accepted best ally for Twitch that will no matter what be his best teammate. However, overall, Cassiopeia is a decent ally for Twitch. By locking into the same side as Twitch, she raises their win rate by 2.5% to 52.5%. This clearly indicates that there is a potentially meaningful synergy between Twitch and Cassiopeia that results in them performing stronger together than alone.
Cassiopeia has a much greater difficulty compared to Twitch. That means Twitch players should be cautious when finding Cassiopeia teammates to fight alongside, as they will need a much higher level of skill to play well with you.
Working on the same side, you should observe an overall large increase in your team’s ability to deal magical damage. Combined, these champions can deal quite a lot of AP type damage.
Conversely, by grouping Twitch and Cassiopeia together, you may not be providing your other allies a lot of cover. Plan to bring other champs on your team that fills this relative disparity in their capabilities.
Regardless of the ability of your Cassiopeia teammate, you should focus on maximizing your gold income, warding to avoid ambushes, and taking down objectives. If you do this, you should do well anyway.
If you would like to truly master Twitch in order to work well with Cassiopeia during both the lane and mid / late game phases of League matches, you should keep reading to pick up a few extra tricks and insights into this champion pairing. If you use the build and stats presented here, you will increase your win rate by a lot.
The most crucial finished items to focus on in your Twitch and Cassiopeia synergy build include Runaan's Hurricane, Guinsoo's Rageblade, and Blade of The Ruined King. When Twitch combined at least these three finished items in his build, he performed significantly better as an ally of Cassiopeia than with many other typical builds. In fact, Twitch boasted an average win rate of 52.5% when synergizing his build and playstyle to Cassiopeia with these items in his kit.
To have the best chance of crushing your oponents, you should equip the Lethal Tempo, Presence of Mind, Legend: Alacrity, Coup de Grace, Taste of Blood, and Treasure Hunter runes from the Precision and Domination rune sets. Of all the runes players used for this champion pairing, this combo of runes yielded the best win rate. In fact, these runes averaged a 52.5% win rate overall.
If you want to view Twitch and Cassiopeia synergy tips and stats for a a distinct skill level, please choose one from the selection menu shown above. If viewing for the first time, the statistics and strategies given are calculated using every round finished with both champions.