Contaminate has a large range; apply as many stacks of Deadly Venom as possible before using it.
You can catch up to an enemy out of attack range with Venom Cask.
Twitch's Attack Speed is among the highest in the game; try purchasing items with on-hit effects such as Black Cleaver or Wit's End.
Molten Shield is a good spell to cast to work up to Annie's stun, so sometimes it's beneficial to grab at least 1 rank in it early.
Striking killing blows on minions with Disintegrate enables Annie to farm extremely well early in the game.
Storing a stun for use with her ultimate can turn the tide of a team fight.
The Twitch Annie synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Annie, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Twitch sees a large worsening in his KDA (ratio of kills and assists to deaths) when paired with Annie. His KDA went down from NaN to NaN. This drop shows that Annie helps Twitch perform poorer in ranked League matches. Yet, the small difference demonstrates that this performance change is not very impactful.
When Twitch is an ally to Annie, he sees a little decrease in his full damage output. This change may signal that Annie does not help cover for him to deal more damage or that her allyship also helps increase the round's duration. Similarly, when Twitch is played together with Annie on the same side, he usually scores many fewer killing sprees than when he plays without Annie. This is contrasting evidence that he is worse when playing alongside Annie.
Moreover, when Twitch plays with Annie on the same team, he usually receives a little less damage than when he plays alone. Taking not as much damage could mean that Annie does a decent job of covering Twitch during teamfights.
There is no top companion for Twitch that will 100% of the time be his ideal synergy. Yet, overall, Annie is a very typical companion for Twitch. By playing on the same side as Twitch, she lowers their win rate by -0.6% to 49.4%. This demonstrates that there is only a small synergy between Twitch and Annie that results in them performing not as well together than alone.
Annie has a lower difficulty than Twitch. That means you don't need to be cautious when enlisting Annie comrades to play with, as they will need a relatively low level of skill to fight well with you.
When playing cooperatively, you should witness an overall large increase in your team’s capacity to deal magic damage. Together, these champs are able to dish out a surprising amount of magic type damage.
In contrast, by bringing Twitch and Annie together, you will not be providing your other allies a great deal of engage potential. Plan to pick other champions on your team that nullifies this hole in this pairing's abilities.
Regardless of your Annie ally's ability, you should focus on increasing your gold income, staying alive by avoiding foolish fights, and clearing objectives. If you follow these simple suggestions, you will do well anyway.
If you would like to truly master Twitch in order to synergize with Annie during both the early game and mid / late game phases of LoL matches, you should continue reading to gather a few extra tips and tricks for this champion pairing. If you pay attention to the build and stats displayed here, you should grow your win rate significantly.
The most important items to focus on in your Twitch and Annie synergy build include Runaan's Hurricane, Guinsoo's Rageblade, and Terminus. When Twitch incorporated at least these three great items in his build, he performed much better when paired up with Annie than with many other commonly used item sets. In fact, Twitch boasted an average winrate of 49.4% helping carry Annie with these items in his kit.
To have the best probability of beating your oponents, Twitch players should equip the Hail of Blades, Taste of Blood, Eyeball Collection, Treasure Hunter, Legend: Alacrity, and Presence of Mind runes from the Domination and Precision rune sets. Out of all the rune sets players chose for Twitch and Annie pairings, this combination of runes yielded the greatest win rate. In fact, these runes gave a 49.4% win rate overall.
If you need to view Twitch and Annie collaboration tips and stats for a a particular division, please choose one from the selection menu above. At first, the statistics and build suggestions displayed are calculated using every round finished with these champions.