Twisted Fate is viable as an Attack Damage or Ability Power character, letting him fit on many different team compositions.
Stealth characters often escape a battle with very low hit points. Take advantage of Destiny's ability to reveal stealthed units to finish them off.
Coordinate with your allies for the best time to use Destiny to ambush enemies.
Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
The Twisted Fate Karthus synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Karthus, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Twisted Fate sees a large worsening in his KDA (ratio of kills and assists to deaths) when paired with Karthus. His KDA decreased from NaN to NaN. This negative change shows that Karthus helps Twisted Fate perform not as well in competitive League of Legends matches. Yet, the small difference shows that this performance change is only marginal.
When Twisted Fate is an ally to Karthus, he sees a little drop in his total damage output. This difference could signal that Karthus doesn't help cover for him to deal more damage or that his presence also helps increase the match's duration. Similarly, when Twisted Fate is played alongside Karthus on the same team, he usually scores many fewer killing sprees than when he plays alone. This is contrasting evidence that he is worse when playing synergisticly with Karthus.
Additionally, when Twisted Fate plays with Karthus on the same team, he often takes more damage than when he plays alone. Taking more damage may mean that Karthus does a poor job of protecting Twisted Fate during teamfights.
There is no universally accepted best champion pairing for Twisted Fate that will 100% of the time be his top ally. However, overall, Karthus is a terrible teammate for Twisted Fate. By locking into the same team as Twisted Fate, he drops their win rate by -3.3% to 47.2%. This signals that there is a terrible synergy between Twisted Fate and Karthus that results in them performing worse together than alone.
Karthus has a lower difficulty than Twisted Fate. That means you don't need to be careful when arranging Karthus teammates to fight alongside, as they will require a relatively low level of skill to be able to cooperate well with you.
Working on the same side, you will likely observe an overall large increase in your team’s capability to to do a lot of AP damage. Combined, these champs can blast through enemies with magic damage.
Although, by grouping Twisted Fate and Karthus together, you will not be granting your other allies very much engage potential. Plan to include other champions on your team that nullifies this gap in this pairing's kit.
Regardless of the ability of your Karthus teammate, you should focus on maximizing your gold income, warding to avoid ambushes, and clearing objectives. If you heed this simple advice, you will do well, regardless.
To truly master Twisted Fate to pair well with Karthus during both the early game and mid / late game phases of League of Legends games, you should keep reading to gather additional tricks and insights into this champion pairing. If you listen to the build and suggestions presented here, you will grow your win rate by a lot.
The most crucial items to use in your Twisted Fate and Karthus synergy build consist of Rabadon's Deathcap, Lich Bane, and Stormsurge. When Twisted Fate included at least these three great items in his build, he performed significantly better when fighting alongside Karthus than with many other commonly used builds. In fact, Twisted Fate had an average winrate of 47.2% helping carry Karthus with these items in his kit.
To have the highest probability of annihilating your oponents, you should use the First Strike, Magical Footwear, Minion Dematerializer, Cosmic Insight, Absolute Focus, and Gathering Storm runes from the Inspiration and Sorcery rune sets. Out of all the rune sets players used for Twisted Fate and Karthus pairings, this sequence of runes resulted in the best win rate. Notably, these runes averaged a 47.2% winrate overall.
If you need to get Twisted Fate and Karthus collaboration tips and builds for a a specific player tier, please select one from the selection menu provided above. At first, the statistics and strategies displayed are computed using all rounds played with these champs.