To maximize your ultimate's damage use it when there are many spheres on the battlefield.
After you hit an enemy champion with Force of Will follow up with Dark Sphere, they'll be slowed and have a hard time avoiding it.
Get one of your spells to rank 5 as quickly as possible, they gain powerful bonus effects at max rank.
Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
The Syndra Karthus synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Karthus, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Syndra sees a very large drop in her KDA (ratio of kills and assists to deaths) when paired with Karthus. His KDA worsened from NaN to NaN. This decrease shows that Karthus helps Syndra perform worse in competitive League rounds. Yet, the small difference shows that this performance change is not very impactful.
When Syndra tries to synergize with Karthus, she observes a barely noticable drop in her total damage dealt. This change could demonstrate that Karthus does not provide protection for her to deal more damage or that his presence on the team also helps extend the match's duration. Similarly, when Syndra is played alongside Karthus on the same team, he usually scores many fewer killing sprees than when she plays alone. This is contrasting evidence that she is worse when playing with Karthus.
Additionally, when Syndra plays with Karthus on the same side, she on average takes more damage than when she fights alone. Taking more damage could mean that Karthus does a poor job of protecting Syndra in team fights.
There is no universally accepted best champion pairing for Syndra that will 100% of the time be her best teammate. Yet, overall, Karthus is a terrible teammate for Syndra. By playing on the same team as Syndra, he decreases their win rate by -6.3% to 42.4%. This clearly indicates that there is an easy to overcome and exploit strategic relationship between Syndra and Karthus that results in them performing worse together than alone.
Karthus has a lower difficulty than Syndra. That means Syndra players don't need to be very careful when lining up Karthus comrades to play with, as they will need a relatively low level of skill to fight well with you.
Working cooperatively, Syndra players should expect to see an overall large increase in your team’s capacity to deal magical damage. When paired, these two can blast through enemies with magic damage.
In contrast, by aligning Syndra and Karthus together, you will not be giving your team very much AD. We recommend you have other champs on your team that neutralizes this gap in their capabilities.
Regardless of your Karthus ally's ability, you need to focus on maximizing your income, staying alive by avoiding foolish fights, and taking down objectives. If you heed this simple advice, you should do well, regardless.
If you would like to learn all of the intricacies of Syndra to synergize with Karthus during both the lane and mid / late game phases of League matches, you should keep reading to learn additional tricks and insights into this champion pairing. If you use the build and tips shown above, you will grow your win rate by a lot.
The top items to focus on in your Syndra and Karthus synergy build include Rabadon's Deathcap, Shadowflame, and Stormsurge. When Syndra used at least these three great items in her build, she did a lot better when fighting alongside Karthus than with many other commonly used builds. In fact, Syndra had an average winrate of 42.4% when playing alongside Karthus with these items in her kit.
To have the highest likelihood of defeating your oponents, you should take the First Strike, Magical Footwear, Minion Dematerializer, Cosmic Insight, Manaflow Band, and Transcendence runes from the Inspiration and Sorcery rune sets. Out of all the runes players used for this team composition, this mixture of runes resulted in the best win rate. Notably, these runes averaged a 42.4% win rate overall.
By default, tips, statistics, and builds on how to team up Karthus with Syndra are shown for every ranked division. If you want to filter the stats and builds to a distinct player tier, you may use the selection menu located earlier on the page.