Don't go in first to a large teamfight. Wait for your teammates to initiate.
Tumble has many uses, but it cannot pass over walls.
Condemn can be used to both pin targets to walls to ensure a kill, or to escape a pursuer.
The Sett Vayne synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Vayne, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Sett sees a large worsening in his KDA (ratio of kills and assists to deaths) when paired with Vayne. His KDA went down from NaN to NaN. This fall shows that Vayne helps Sett perform not as well in ranked LoL rounds. Yet, the small difference indicates that this performance change is not very impactful.
When Sett tries to synergize with Vayne, he gets a barely noticable drop in his complete damage dealt. This difference could demonstrate that Vayne doesn't help protection for him to dish out more damage or that her allyship also helps extend the match's duration. Similarly, when Sett is played alongside Vayne on the same team, he usually scores many fewer killing sprees than when he plays alone. This is contrasting evidence that he is worse when playing with Vayne.
Moreover, when Sett plays with Vayne on the same team, he on average takes a little less damage than when he fights alone. Getting dealt not as much damage may indicate that Vayne does a decent job of covering Sett during team fights.
There is no ideal companion for Sett that will no matter what be his #1 teammate. However, overall, Vayne is a pretty good ally for Sett. By playing on the same team as Sett, she raises their win rate by 1.3% to 51.8%. This demonstrates that there is a potentially meaningful bond between Sett and Vayne that allows them to perform stronger together than without each other.
Vayne has a much greater difficulty compared to Sett. That means Sett players need to be very careful when lining up Vayne comrades to go into battle on the same side as, as they will need a much higher level of skill to be able to fight well with you.
Working alongside, you will likely witness an overall large increase in your team’s capability to dish out massive AD. Combined, these champs can tear through the other team with a lot of physcial damage.
In contrast, by bringing Sett and Vayne together, you may not be giving your side a lot of magical damage output. Make sure to include other champions on your team that nullifies this relative disparity in this pairing's potential.
Regardless of your Vayne ally's skill level, you should focus on increasing your gold income, warding to avoid ambushes, and taking down objectives. If you heed this simple advice, you should do well anyway.
If you would like to truly master Sett in order to synergize with Vayne during both the laning and mid / late game phases of League of Legends, you should continue reading to gather additional lessons on this champion pairing. If you listen to the build and stats shown above, you will grow your win rate significantly.
The ideal finished items to use in your Sett and Vayne synergy build include Sterak's Gage, Trinity Force, and Titanic Hydra. When Sett included at least these three great items in his build, he did significantly better when paired up with Vayne than with many other typical builds. In fact, Sett had an average win rate of 51.8% helping carry Vayne with these items in his kit.
To have the greatest likelihood of annihilating your oponents, Sett players should use the Grasp of the Undying, Demolish, Second Wind, Overgrowth, Last Stand, and Triumph runes from the Resolve and Precision rune sets. Of all the runes players chose for Sett and Vayne pairings, this order of runes yielded the greatest win rate. Notably, these runes gave a 51.8% winrate overall.
By default, tips, stats, and builds on how to pair Vayne with Sett are presented for all skill levels, merged. If you want to narrow the stats and builds to a specific division, you should use the selection menu earlier in the counter matchup guide.