Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
The Seraphine Karthus synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Karthus, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Seraphine sees a very large drop in her KDA (ratio of kills and assists to deaths) when paired with Karthus. His KDA worsened from NaN to NaN. This worsening shows that Karthus helps Seraphine perform worse in competitive League of Legends matches. Yet, the small difference shows that this performance change is only marginal.
When Seraphine is an ally to Karthus, she sees a little drop in her full damage dealt. This change could indicate that Karthus doesn't help protection for her to dish out more damage or that his participation also helps increase the game's duration. Similarly, when Seraphine is played alongside Karthus on the same team, he usually scores many fewer killing sprees than when she plays on his own. This is contrasting evidence that she is worse when playing alongside Karthus.
Moreover, when Seraphine plays with Karthus on the same side, she typically receives more damage than when she fights alone. Taking more damage could mean that Karthus does a poor job of protecting Seraphine in team fights.
There is no top champion pairing for Seraphine that will no matter what be her #1 teammate. Yet, overall, Karthus is a terrible teammate for Seraphine. By locking into the same side as Seraphine, he drops their win rate by -3.5% to 46.5%. This clearly indicates that there is an easy to overcome and exploit strategic relationship between Seraphine and Karthus that results in them performing not as well together than without each other.
Karthus has a much greater difficulty compared to Seraphine. That means Seraphine players should be cautious when enlisting Karthus teammates to fight alongside, as they will have to have a much higher level of skill to fight well with you.
When playing together, you should observe an overall large increase in your team’s ability to provide utility and CC for your side. Combined, these champs will help their other teammates secure a victory.
Conversely, by aligning Seraphine and Karthus together, you probably will not be giving your other allies a great deal of AD. We recommend you have other champs on your team that offsets this relative hole in their potential.
Regardless of your Karthus ally's skill level, you should focus on increasing your income, warding to avoid ambushes, and taking down objectives. If you do this, you will do well, regardless.
If you would like to learn all of the intricacies of Seraphine in order to synergize with Karthus during both the early game and mid / late game phases of LoL rounds, you should continue reading to pick up some more tricks and insights into this champion pairing. If you listen to the build and suggestions presented above, you will grow your win rate by a lot.
The best finished items to get in your Seraphine and Karthus synergy build consist of Seraph's Embrace, Staff of Flowing Water, and Dawncore. When Seraphine bought at least these three pieces in her build, she performed significantly better when fighting alongside Karthus than with most other typical item sets. In fact, Seraphine boasted an average winrate of 46.5% helping carry Karthus with this build.
To have the greatest probability of annihilating your oponents, Seraphine players should take the Arcane Comet, Manaflow Band, Transcendence, Scorch, Biscuit Delivery, and Cosmic Insight runes from the Sorcery and Inspiration rune sets. Out of all the rune builds we have analyed for Seraphine and Karthus pairings, this blending of runes yielded the top win rate. Moreover, these runes provided a 46.5% win rate overall.
If you need to view Seraphine with Karthus cooperations tips and builds for a a particular division, feel free to select one from the selection menu provided above. If viewing for the first time, the stats and strategies shown are calculated using every game with data with these champs.