Lead your enemy when targeting with Noxious Blast to ensure the hit.
Use Twin Fang on poisoned stationary targets like monsters and units stunned by her Petrifying Gaze for maximum damage.
The Seraphine Cassiopeia synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Cassiopeia, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Seraphine sees a very large drop in her KDA (ratio of kills and assists to deaths) when paired with Cassiopeia. His KDA decreased from NaN to NaN. This worsening shows that Cassiopeia helps Seraphine perform not as well in ranked League of Legends rounds. Yet, the small difference indicates that this performance change is only marginal.
When Seraphine is paired with Cassiopeia, she sees a barely noticable drop in her total damage output. This may indicate that Cassiopeia does not support by providing cover for her to dish out more damage or that her participation also helps extend the match's duration. Similarly, when Seraphine is played alongside Cassiopeia on the same side, he usually scores many fewer killing sprees than when she plays on his own. This is contrasting evidence that she is worse when playing synergisticly with Cassiopeia.
Additionally, when Seraphine plays with Cassiopeia on the same team, she typically takes a little more damage than when she fights alone. Receiving more damage may mean that Cassiopeia does a poor job of protecting Seraphine during teamfights.
There is no one best synergy for Seraphine that will no matter what be her best teammate. Yet, Cassiopeia is a very typical teammate for Seraphine. By being on the same side as Seraphine, she increases their win rate by 0.3% to 50.3%. This demonstrates that there is not really a strong bond between Seraphine and Cassiopeia that results in them performing at the top of their game together than alone.
Cassiopeia has a much greater difficulty compared to Seraphine. That means you must be very careful when finding Cassiopeia comrades to go into battle on the same side as, as they will need a much greater level of skill to work well with you.
Working alongside, Seraphine players should witness an overall large increase in your team’s capacity to provide a lot of utility for your team. When paired, these two will help their other teammates secure a victory.
In contrast, by bringing Seraphine and Cassiopeia together, you will not be granting your other teammates enough anti-tank damage dealing potential. Plan to pick other champs on your team that fills this relative hole in this pairing's capabilities.
Regardless of the skill of your Cassiopeia ally, you need to focus on maximizing your gold income, staying alive by avoiding foolish fights, and taking down objectives. If you do this, you will do well, regardless.
To truly master Seraphine in order to synergize with Cassiopeia during both the lane and mid / late game phases of League of Legends games, you should continue reading to master additional tricks and insights into this champion pairing. If you pay attention to the build and tips presented above, you will grow your win rate significantly.
The most crucial items to have in your Seraphine and Cassiopeia synergy build consist of Dream Maker, Moonstone Renewer, and Dawncore. When Seraphine incorporated at least these three pieces in her build, she did much better when paired up with Cassiopeia than with most other typical builds. In fact, Seraphine boasted an average win rate of 50.3% when synergizing her build and playstyle to Cassiopeia with this build.
To have the best likelihood of crushing your oponents, Seraphine players should use the Summon Aery, Manaflow Band, Transcendence, Scorch, Bone Plating, and Revitalize runes from the Sorcery and Resolve rune sets. Of all the rune sets players chose for Seraphine and Cassiopeia pairings, this sequence of runes resulted in the highest win rate. In fact, these runes provided a 50.3% winrate overall.
By default, tips, stats, and builds on how to pair Cassiopeia with Seraphine are displayed for every ranked division. If you want to filter the stats and builds to a particular rank, you should use the selection menu located earlier on the page.