Don't go in first to a large teamfight. Wait for your teammates to initiate.
Tumble has many uses, but it cannot pass over walls.
Condemn can be used to both pin targets to walls to ensure a kill, or to escape a pursuer.
The Senna Vayne synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Vayne, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Senna sees a large worsening in her KDA (ratio of kills and assists to deaths) when paired with Vayne. His KDA decreased from NaN to NaN. This fall shows that Vayne helps Senna perform worse in competitive LoL rounds. Yet, the small difference proves that this performance change is only marginal.
When Senna tries to synergize with Vayne, she sees a small decrease in her full damage output. This change could demonstrate that Vayne does not support by providing cover for her to dish out more damage or that her allyship also helps increase the match's duration. Similarly, when Senna is played alongside Vayne on the same team, he usually scores many fewer killing sprees than when she plays on his own. This is contrasting evidence that she is worse when playing synergisticly with Vayne.
Moreover, when Senna plays with Vayne on the same side, she on average takes a little less damage than when she plays alone. Getting dealt not as much damage could mean that Vayne does a decent job of covering Senna in teamfights.
There is no top ally for Senna that will always be her best teammate. However, Vayne is a very typical companion for Senna. By being on the same team as Senna, she drops their win rate by -0.8% to 50.0%. This proves that there is a weak bond between Senna and Vayne that results in them performing not as well together than without each other.
Vayne has a greater difficulty than Senna. That means Senna players must be very careful when finding Vayne teammates to fight alongside, as they will need a greater level of skill to be able to play well with you.
Working on the same side, Senna players will likely observe an overall large increase in your team’s ability to destroy wih physical damage. Together, these champs should be able to take down targets with auto-attacks and other AD damage abilities.
Conversely, by grouping Senna and Vayne together, you may not be giving your other teammates very much tankyness. We recommend you pick other champions on your team that helps cover this relative disparity in this pairing's potential.
Regardless of your Vayne ally's ability, you need to focus on maximizing your gold income, warding to avoid ambushes, and clearing objectives. If you follow these simple suggestions, you should do well, regardless.
To truly master Senna in order to synergize with Vayne during both the lane and mid / late game phases of League, you should keep reading to pick up additional tricks and insights into this champion pairing. If you listen to the build and tips shown above, you should grow your win rate significantly.
The best finished items to build first in your Senna and Vayne synergy build include Rapid Firecannon, Youmuu's Ghostblade, and The Collector. When Senna used at least these three great items in her build, she did much better when fighting alongside Vayne than with many other commonly used item sets. In fact, Senna boasted an average win rate of 50.0% helping carry Vayne with these items in her kit.
To have the best probability of defeating your oponents, Senna players should use the Fleet Footwork, Presence of Mind, Legend: Alacrity, Cut Down, Biscuit Delivery, and Approach Velocity runes from the Precision and Inspiration rune sets. Of all the rune combinations players picked for Senna and Vayne pairings, this mixture of runes resulted in the greatest win rate. In fact, these runes provided a 50.0% winrate overall.
By default, tips, stats, and builds on how to synergize Vayne with Senna are displayed for all skill levels combined. If you want to filter the statistics and builds to a specific player tier, you can use the selection menu located earlier on the page.