Contaminate has a large range; apply as many stacks of Deadly Venom as possible before using it.
You can catch up to an enemy out of attack range with Venom Cask.
Twitch's Attack Speed is among the highest in the game; try purchasing items with on-hit effects such as Black Cleaver or Wit's End.
The Senna Twitch synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Twitch, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Senna sees a large worsening in her KDA (ratio of kills and assists to deaths) when paired with Twitch. His KDA decreased from NaN to NaN. This decrease shows that Twitch helps Senna perform worse in competitive League of Legends rounds. Yet, the small difference shows that this performance change is only marginal.
When Senna tries to synergize with Twitch, she gets a little drop in her complete damage dealt. This change may demonstrate that Twitch does not provide protection for her to dish out more damage or that his allyship also helps increase the game's duration. Similarly, when Senna is played together with Twitch on the same team, he usually scores many fewer killing sprees than when she plays alone. This is contrasting evidence that she is worse when playing synergisticly with Twitch.
Moreover, when Senna plays with Twitch on the same side, she typically receives a little more damage than when she plays alone. Receiving more damage may mean that Twitch does a poor job of covering Senna during teamfights.
There is no one best ally for Senna that will no matter what be her #1 teammate. However, overall, Twitch is a terrible ally for Senna. By being on the same side as Senna, he decreases their win rate by -3.1% to 47.7%. This shows that there is an easy to overcome and exploit synergy between Senna and Twitch that allows them to perform worse together than without each other.
Twitch has a lower difficulty than Senna. That means you don't need to be cautious when lining up Twitch teammates to fight alongside, as they will need a relatively low level of skill to cooperate well with you.
Fighting on the same side, you should expect to observe an overall large increase in your team’s ability to dish out massive AD. When paired, these champions should be able to take down targets with auto-attacks and other AD damage abilities.
Although, by pairing Senna and Twitch together, you may not be granting your team a great deal of tankyness. We recommend you have other champs on your team that helps cover this relative hole in their kit.
Regardless of your Twitch ally's skill level, you need to focus on increasing your income, warding to avoid ambushes, and taking down objectives. If you heed this simple advice, you should do well anyway.
To learn all of the intricacies of Senna to pair well with Twitch during both the lane and mid / late game phases of LoL, you should continue reading to pick up additional lessons on this champion pairing. If you listen to the build and suggestions shown here, you will increase your win rate by a lot.
The ideal items to have in your Senna and Twitch synergy build include Youmuu's Ghostblade, Bloodsong, and Opportunity. When Senna bought at least these three items in her build, she did a lot better as an ally of Twitch than with many other common builds. In fact, Senna had an average winrate of 47.7% when synergizing her build and playstyle to Twitch with these items in her kit.
To have the highest likelihood of vanquishing your oponents, you should take the Fleet Footwork, Presence of Mind, Legend: Alacrity, Cut Down, Bone Plating, and Revitalize runes from the Precision and Resolve rune sets. Of all the runes players picked for Senna and Twitch pairings, this mix of runes resulted in the highest win rate. In fact, these runes provided a 47.7% winrate overall.
By default, tips, stats, and builds on how to synergize Twitch with Senna are given for all skill levels combined. To narrow the statistics and builds to a particular division, you can use the selection menu located earlier on the page.