Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
The Senna Karthus synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Karthus, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Senna sees a very large drop in her KDA (ratio of kills and assists to deaths) when paired with Karthus. His KDA went down from NaN to NaN. This drop shows that Karthus helps Senna perform not as well in ranked LoL rounds. Yet, the small difference proves that this performance change is not very impactful.
When Senna plays on the same team as Karthus, she observes a little decrease in her complete damage dealt. This may indicate that Karthus does not provide cover for her to deal more damage or that his participation also helps increase the round's duration. Similarly, when Senna is played together with Karthus on the same side, he usually scores many fewer killing sprees than when she plays without Karthus. This is contrasting evidence that she is worse when playing with Karthus.
Moreover, when Senna plays with Karthus on the same team, she on average takes more damage than when she fights alone. Getting dealt more damage could indicate that Karthus does a poor job of protecting Senna in teamfights.
There is no perfect companion for Senna that will always be her ideal teammate. Yet, overall, Karthus is a very bad companion for Senna. By locking into the same side as Senna, he lowers their win rate by -3.8% to 47.0%. This shows that there is a terrible bond between Senna and Karthus that allows them to perform worse together than alone.
Karthus has a lower difficulty than Senna. That means you don't need to be very careful when enlisting Karthus allies to go into battle on the same side as, as they will need a lower level of skill to work well with you.
Working cooperatively, Senna players will likely witness an overall large increase in your team’s capacity to to do a lot of AP damage. When paired, these two can deal quite a lot of AP type damage.
Although, by aligning Senna and Karthus together, you will not be granting your other allies enough engage. Plan to have other champions on your team that neutralizes this relative gap in this pairing's abilities.
Regardless of the skill of your Karthus ally, you should focus on maximizing your income, warding to avoid ambushes, and taking down objectives. If you heed this simple advice, you should do well, regardless.
To truly master Senna in order to synergize with Karthus during both the lane and mid / late game phases of LoL games, you should continue reading to pick up some more tips and tricks for this champion pairing. If you use the build and tips displayed here, you will grow your win rate significantly.
The ideal finished items to prioritize in your Senna and Karthus synergy build include Lord Dominik's Regards, Bloodsong, and The Collector. When Senna included at least these three pieces in her build, she did a lot better when fighting alongside Karthus than with many other commonly used item sets. In fact, Senna had an average win rate of 47.0% when playing alongside Karthus with these items in her kit.
To have the greatest chance of defeating your oponents, Senna players should use the Fleet Footwork, Presence of Mind, Legend: Alacrity, Cut Down, Bone Plating, and Revitalize runes from the Precision and Resolve rune sets. Out of all the rune sets players chose for Senna and Karthus pairings, this composite of runes yielded the top win rate. Notably, these runes provided a 47.0% win rate overall.
If you want to get Senna with Karthus cooperations tips and stats for a a particular division, feel free to choose one from the selection menu shown above. If viewing for the first time, the stats and build suggestions displayed are calculated using every match finished with both champs.