Make sure to buy items that will evolve at least 1 or 2 of your spells.
Work with your teammates to set up your Ultimate and optimize damage with your passive.
Try to catch enemy carries alone to burst them with Icathian Rain.
The Senna Kai'Sa synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Kai'Sa, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Senna sees a very large drop in her KDA (ratio of kills and assists to deaths) when paired with Kai'Sa. His KDA went down from NaN to NaN. This worsening shows that Kai'Sa helps Senna perform poorer in competitive League games. Yet, the small difference demonstrates that this performance change is only marginal.
When Senna is paired with Kai'Sa, she sees a barely noticable drop in her total damage output. This change may signal that Kai'Sa doesn't help cover for her to deal more damage or that her support also helps extend the game's duration. Similarly, when Senna is played with Kai'Sa on the same team, he usually scores many fewer killing sprees than when she plays alone. This is contrasting evidence that she is worse when playing synergisticly with Kai'Sa.
Moreover, when Senna plays with Kai'Sa on the same team, she usually receives a little more damage than when she fights alone. Taking more damage could indicate that Kai'Sa does a poor job of covering Senna during team fights.
There is no top companion for Senna that will always be her best ally. Yet, overall, Kai'Sa is a very bad teammate for Senna. By locking into the same side as Senna, she drops their win rate by -5.9% to 44.9%. This demonstrates that there is a very bad bond between Senna and Kai'Sa that allows them to perform worse together than without each other.
Kai'Sa has a lower difficulty than Senna. That means Senna players don't need to be careful when lining up Kai'Sa comrades to play with, as they will require a relatively low level of skill to play well with you.
Playing on the same side, you should expect to witness an overall large increase in your team’s capability to deal physical damage. When paired, these champs should be able to take down targets with auto-attacks and other AD damage abilities.
Conversely, by pairing Senna and Kai'Sa together, you may not be granting your team very much protection for burst damage. Plan to pick other champs on your team that fills this relative gap in this pairing's potential.
Regardless of your Kai'Sa ally's skill level, you should focus on increasing your gold income, outlasting your enemies, and taking down objectives. If you heed this simple advice, you should do well anyway.
To truly master Senna to synergize with Kai'Sa during both the laning and mid / late game phases of LoL games, you should keep reading to master additional lessons on this champion pairing. If you use the build and stats presented here, you will increase your win rate significantly.
The best items to use in your Senna and Kai'Sa synergy build include Youmuu's Ghostblade, Edge of Night, and Bloodsong. When Senna incorporated at least these three great items in her build, she did a lot better when paired up with Kai'Sa than with many other commonly used item sets. In fact, Senna boasted an average win rate of 44.9% when playing alongside Kai'Sa with this build.
To have the greatest chance of vanquishing your oponents, Senna players should take the Fleet Footwork, Presence of Mind, Legend: Alacrity, Cut Down, Approach Velocity, and Biscuit Delivery runes from the Precision and Inspiration rune sets. Out of all the rune builds players picked for this team composition, this mix of runes resulted in the greatest win rate. Moreover, these runes averaged a 44.9% win rate overall.
If you would like to see Senna and Kai'Sa synergy tips and builds for a a specific division rank, please select one from the selection menu shown above. If viewing for the first time, the statistics and strategies given are computed using every game completed with both champs.