Spider Form is most effective at finishing off enemies with low health; Human Form's Neurotoxin does more damage to healthy foes.
Elise's Spider Form and Spider Form abilities do not cost mana and can be prioritized when you are trying to conserve mana.
When in Spider Form, Spiderlings will attack the target that Elise uses Venomous Bite on.
The Senna Elise synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Elise, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Senna sees a very large drop in her KDA (ratio of kills and assists to deaths) when paired with Elise. His KDA went down from NaN to NaN. This negative change shows that Elise helps Senna perform worse in ranked LoL rounds. Yet, the small difference shows that this performance change is only marginal.
When Senna is paired with Elise, she gets a little decrease in her complete damage output. This could indicate that Elise does not provide protection for her to deal more damage or that her support also helps increase the round's duration. Similarly, when Senna is played with Elise on the same team, he usually scores many fewer killing sprees than when she plays on his own. This is contrasting evidence that she is worse when playing synergisticly with Elise.
Additionally, when Senna plays with Elise on the same team, she often takes a little less damage than when she fights alone. Taking not as much damage may mean that Elise does a decent job of protecting Senna in teamfights.
There is no one best companion for Senna that will no matter what be her best teammate. However, overall, Elise is a relatively poor companion for Senna. By playing on the same side as Senna, she decreases their win rate by -1.1% to 49.7%. This clearly indicates that there is a negative synergy between Senna and Elise that allows them to perform not as well together than alone.
Elise has a greater difficulty than Senna. That means you need to be cautious when arranging Elise comrades to fight alongside, as they will have to have a greater level of skill to do well with you.
Playing together, you should expect to observe an overall large increase in your team’s capacity to deal physical damage. Together, these two can tear through the other team with a lot of physcial damage.
In contrast, by aligning Senna and Elise together, you may not be giving your other allies enough tankyness. Plan to include other champions on your team that neutralizes this relative disparity in this pairing's kit.
Regardless of the ability of your Elise teammate, you need to focus on maximizing your income, outlasting your enemies, and taking down objectives. If you do this, you should do well, regardless.
If you would like to learn all of the intricacies of Senna to pair well with Elise during both the lane and mid / late game phases of LoL, you should continue reading to gather a few extra tips and tricks for this champion pairing. If you use the build and stats shown here, you will increase your win rate significantly.
The top items to prioritize in your Senna and Elise synergy build include Rapid Firecannon, Youmuu's Ghostblade, and Umbral Glaive. When Senna combined at least these three finished items in her build, she performed much better as an ally of Elise than with most other typical item sets. In fact, Senna had an average winrate of 49.7% helping carry Elise with this build.
To have the highest likelihood of defeating your oponents, you should take the Fleet Footwork, Presence of Mind, Legend: Alacrity, Cut Down, Approach Velocity, and Biscuit Delivery runes from the Precision and Inspiration rune sets. Out of all the rune sets players picked for this team composition, this mix of runes yielded the highest win rate. Moreover, these runes averaged a 49.7% winrate overall.
If you would like to see Senna with Elise cooperations tips and stats for a a distinct division, feel free to choose one from the selection menu displayed above. At first, the statistics and guides given are computed using every game finished with both champions.