Spell Flux's short cooldown allows it to be used to spread Flux to many enemies.
Use Overload's passive to optimize for maximum damage or maximum speed.
Ryze can move and cast other spells while Realm Warp is charging without cancelling the portal.
Don't go in first to a large teamfight. Wait for your teammates to initiate.
Tumble has many uses, but it cannot pass over walls.
Condemn can be used to both pin targets to walls to ensure a kill, or to escape a pursuer.
The Ryze Vayne synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Vayne, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Ryze sees a large worsening in his KDA (ratio of kills and assists to deaths) when paired with Vayne. His KDA decreased from NaN to NaN. This fall shows that Vayne helps Ryze perform worse in competitive League rounds. Yet, the small difference shows that this performance change is only marginal.
When Ryze tries to synergize with Vayne, he observes a small decrease in his complete damage dealt. This change could indicate that Vayne does not help protection for him to deal more damage or that her support also helps extend the game's duration. Similarly, when Ryze is played alongside Vayne on the same side, he usually scores many fewer killing sprees than when he plays without Vayne. This is contrasting evidence that he is worse when playing alongside Vayne.
Additionally, when Ryze plays with Vayne on the same team, he usually takes a little less damage than when he plays alone. Taking not as much damage may indicate that Vayne does a decent job of protecting Ryze during team fights.
There is no one best companion for Ryze that will 100% of the time be his #1 synergy. Yet, Vayne is a very bad companion for Ryze. By locking into the same side as Ryze, she drops their win rate by -3.3% to 45.7%. This demonstrates that there is a very bad strategic relationship between Ryze and Vayne that results in them performing not as well together than alone.
Vayne has a greater difficulty than Ryze. That means Ryze players should be very careful when enlisting Vayne comrades to fight alongside, as they will require a greater level of skill to cooperate well with you.
Fighting on the same side, Ryze players should expect to see an overall large increase in your team’s capability to dish out massive AD. When paired, these champs can provide a great amount of sustained physical damage.
In contrast, by grouping Ryze and Vayne together, you may not be granting your team much cover. Make sure to pick other champions on your team that helps cover this relative disparity in this pairing's potential.
Regardless of your Vayne ally's ability, you need to focus on increasing your income, warding to avoid ambushes, and taking down objectives. If you heed this simple advice, you will do well anyway.
To learn all of the intricacies of Ryze to work well with Vayne during both the early game and mid / late game phases of LoL rounds, you should keep reading to master some more tricks and insights into this champion pairing. If you mind the build and suggestions shown above, you should increase your win rate significantly.
The most important finished items to get in your Ryze and Vayne synergy build include Seraph's Embrace, Void Staff, and Rod of Ages. When Ryze used at least these three finished items in his build, he did significantly better when paired up with Vayne than with many other commonly used builds. In fact, Ryze boasted an average win rate of 45.7% helping carry Vayne with these items in his kit.
To have the greatest chance of annihilating your oponents, Ryze players should use the Phase Rush, Manaflow Band, Transcendence, Waterwalking, Biscuit Delivery, and Cosmic Insight runes from the Sorcery and Inspiration rune sets. Out of all the runes we have analyed for this champion pairing, this order of runes resulted in the best win rate. In fact, these runes gave a 45.7% winrate overall.
By default, tips, stats, and builds on how to team up Vayne with Ryze are given for all ranked divisions combined. If you want to scope the stats and builds to a particular player tier, you can use the selection menu earlier in the counter matchup guide.