Don't go in first to a large teamfight. Wait for your teammates to initiate.
Tumble has many uses, but it cannot pass over walls.
Condemn can be used to both pin targets to walls to ensure a kill, or to escape a pursuer.
The Qiyana Vayne synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Vayne, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Qiyana sees a very large drop in her KDA (ratio of kills and assists to deaths) when paired with Vayne. His KDA fell from NaN to NaN. This fall shows that Vayne helps Qiyana perform poorer in competitive League matches. Yet, the small difference proves that this performance change is only marginal.
When Qiyana plays on the same team as Vayne, she sees a barely noticable drop in her total damage output. This change could signal that Vayne does not help protection for her to deal more damage or that her support also helps extend the game's duration. Similarly, when Qiyana is played alongside Vayne on the same side, he usually scores many fewer killing sprees compared to when she plays alone. This is contrasting evidence that she is worse when playing alongside Vayne.
Moreover, when Qiyana plays with Vayne on the same team, she typically receives a little less damage than when she fights alone. Taking not as much damage could indicate that Vayne does a decent job of protecting Qiyana during teamfights.
There is no universally accepted best synergy for Qiyana that will 100% of the time be her #1 synergy. Yet, Vayne is a very typical teammate for Qiyana. By locking into the same team as Qiyana, she lowers their win rate by -0.3% to 47.5%. This proves that there is a weak synergy between Qiyana and Vayne that allows them to perform not as well together than alone.
Vayne has a lower difficulty than Qiyana. That means you don't need to be cautious when lining up Vayne teammates to go into battle on the same side as, as they will require a relatively low level of skill to cooperate well with you.
Working alongside, you will likely witness an overall large increase in your team’s ability to dish out massive AD. Together, these two can tear through the other team with a lot of physcial damage.
Conversely, by bringing Qiyana and Vayne together, you will not be providing your side a great deal of tankyness. Plan to pick other champions on your team that neutralizes this gap in this pairing's potential.
Regardless of the ability of your Vayne ally, you need to focus on maximizing your income, outlasting your enemies, and taking down objectives. If you heed this simple advice, you should do well anyway.
To learn all of the intricacies of Qiyana in order to synergize with Vayne during both the early game and mid / late game phases of League of Legends rounds, you should keep reading to learn a few extra tips and tricks for this champion pairing. If you listen to the build and suggestions shown here, you will increase your win rate by a lot.
The best items to prioritize in your Qiyana and Vayne synergy build include Serylda's Grudge, Hubris, and Profane Hydra. When Qiyana combined at least these three finished items in her build, she performed significantly better when paired up with Vayne than with most other common builds. In fact, Qiyana had an average winrate of 47.5% when synergizing her build and playstyle to Vayne with these items in her kit.
To have the highest chance of crushing your oponents, Qiyana players should use the Electrocute, Sudden Impact, Eyeball Collection, Relentless Hunter, Presence of Mind, and Last Stand runes from the Domination and Precision rune sets. Of all the runes players chose for this champion pairing, this combo of runes yielded the highest win rate. Moreover, these runes averaged a 47.5% winrate overall.
By default, tips, statistics, and builds on how to synergize Vayne with Qiyana are presented for all skill levels combined. If you want to narrow the stats and builds to a specific rank, you may use the selection menu earlier in the counter matchup guide.