Kassadin's ultimate has many uses and is on a shorter cooldown than most, use it often.
Kassadin has multiple item paths; he can go caster via Mana and Ability Power or anti-caster with Cooldown Reduction and Magic Resist.
Try to get the Ancient Golem buff to counteract Riftwalk's increasing Mana cost.
The Qiyana Kassadin synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Kassadin, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Qiyana sees a very large drop in her KDA (ratio of kills and assists to deaths) when paired with Kassadin. His KDA went down from NaN to NaN. This fall shows that Kassadin helps Qiyana perform poorer in ranked League of Legends matches. Yet, the small difference demonstrates that this performance change is not very impactful.
When Qiyana is an ally to Kassadin, she observes a large drop in her total damage output. This difference could demonstrate that Kassadin does not provide cover for her to deal more damage or that his allyship also helps increase the match's duration. Similarly, when Qiyana is played with Kassadin on the same side, he usually scores many fewer killing sprees compared to when she plays without Kassadin. This is contrasting evidence that she is worse when playing synergisticly with Kassadin.
Additionally, when Qiyana plays with Kassadin on the same side, she often takes much more damage than when she fights alone. Receiving more damage may indicate that Kassadin does a poor job of covering Qiyana during teamfights.
There is no ideal champion pairing for Qiyana that will always be her best synergy. Yet, Kassadin is a good teammate for Qiyana. By being on the same team as Qiyana, he raises their win rate by 1.3% to 49.1%. This demonstrates that there is pretty good bond between Qiyana and Kassadin that results in them performing better together than alone.
Kassadin has a lower difficulty than Qiyana. That means Qiyana players don't need to be very careful when lining up Kassadin allies to play with, as they will have to have a relatively low level of skill to be able to fight well with you.
Fighting together, you will likely witness an overall large increase in your team’s capability to deal magic damage. When paired, these champs can deal quite a lot of AP type damage.
Although, by pairing Qiyana and Kassadin together, you may not be granting your team very much AD. Plan to pick other champs on your team that fills this hole in this pairing's kit.
Regardless of your Kassadin ally's skill level, you should focus on maximizing your gold income, warding to avoid ambushes, and taking down objectives. If you follow these simple suggestions, you will do well anyway.
To truly master Qiyana to synergize with Kassadin during both the early game and mid / late game phases of League of Legends rounds, you should keep reading to master a few extra tricks and insights into this champion pairing. If you mind the build and tips shown here, you will increase your win rate by a lot.
The ideal items to have in your Qiyana and Kassadin synergy build consist of Guardian Angel, Youmuu's Ghostblade, and Axiom Arc. When Qiyana included at least these three items in her build, she did much better when fighting alongside Kassadin than with many other common item sets. In fact, Qiyana had an average winrate of 49.1% helping carry Kassadin with this build.
To have the greatest probability of crushing your oponents, Qiyana players should take the First Strike, Magical Footwear, Future's Market, Cosmic Insight, Sudden Impact, and Treasure Hunter runes from the Inspiration and Domination rune sets. Of all the rune builds players chose for this team composition, this combination of runes resulted in the top win rate. Notably, these runes provided a 49.1% winrate overall.
By default, tips, statistics, and builds on how to pair Kassadin with Qiyana are shown for all ranked divisions. If you want to narrow the stats and builds to a distinct division, you should use the selection menu earlier in the counter matchup guide.