The Tap version of Bone Skewer is much faster and deals additional damage.
A lot of your agressive spells are also your escapes. Make sure you always have a plan to get out of the fight.
Hitting an enemy with the Hold version of Bone Skewer will always pull them the same distance. Use it in melee range to throw targets behind you.
Pyke is very fragile so don't be afraid to temporarily run from a fight. You can regenerate a significant amount of health from Gift of the Drowned Ones when enemies can't see you.
Lead your enemy when targeting with Noxious Blast to ensure the hit.
Use Twin Fang on poisoned stationary targets like monsters and units stunned by her Petrifying Gaze for maximum damage.
The Pyke Cassiopeia synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Cassiopeia, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Pyke sees a very large drop in his KDA (ratio of kills and assists to deaths) when paired with Cassiopeia. His KDA went down from NaN to NaN. This decrease shows that Cassiopeia helps Pyke perform poorer in ranked League matches. Yet, the small difference demonstrates that this performance change is not very impactful.
When Pyke is paired with Cassiopeia, he gets a little decrease in his total damage dealt. This could signal that Cassiopeia does not support by providing protection for him to dish out more damage or that her presence also helps increase the match's duration. Similarly, when Pyke is played with Cassiopeia on the same team, he usually scores many fewer killing sprees than when he plays without Cassiopeia. This is contrasting evidence that he is worse when playing synergisticly with Cassiopeia.
Additionally, when Pyke plays with Cassiopeia on the same team, he often receives a little more damage than when he plays alone. Taking more damage could indicate that Cassiopeia does a poor job of covering Pyke in team fights.
There is no one best ally for Pyke that will 100% of the time be his best synergy. However, overall, Cassiopeia is a very typical companion for Pyke. By locking into the same side as Pyke, she decreases their win rate by -0.1% to 49.0%. This proves that there is a weak bond between Pyke and Cassiopeia that allows them to perform worse together than without each other.
Cassiopeia has a greater difficulty than Pyke. That means Pyke players need to be careful when arranging Cassiopeia teammates to go into battle on the same side as, as they will require a greater level of skill to be able to play well with you.
Playing on the same side, Pyke players should expect to observe an overall large increase in your team’s capacity to deal physical damage. Together, these champions should be able to take down targets with auto-attacks and other AD damage abilities.
In contrast, by aligning Pyke and Cassiopeia together, you may not be granting your team a great deal of protection for burst damage. Make sure to have other champions on your team that nullifies this relative gap in this pairing's abilities.
Regardless of the skill of your Cassiopeia teammate, you should focus on increasing your gold income, warding to avoid ambushes, and clearing objectives. If you do this, you will do well, regardless.
If you would like to truly master Pyke to work well with Cassiopeia during both the early game and mid / late game phases of League, you should continue reading to gather some more lessons on this champion pairing. If you use the build and stats presented here, you should grow your win rate significantly.
The most important items to build first in your Pyke and Cassiopeia synergy build consist of Youmuu's Ghostblade, Umbral Glaive, and Bloodsong. When Pyke incorporated at least these three great items in his build, he performed a lot better when fighting alongside Cassiopeia than with most other common item sets. In fact, Pyke had an average win rate of 49.0% when playing alongside Cassiopeia with these items in his kit.
To have the highest probability of crushing your oponents, Pyke players should take the Hail of Blades, Cheap Shot, Zombie Ward, Ultimate Hunter, Bone Plating, and Unflinching runes from the Domination and Resolve rune sets. Out of all the rune combinations players picked for Pyke and Cassiopeia pairings, this combo of runes yielded the top win rate. In fact, these runes gave a 49.0% win rate overall.
If you need to view Pyke and Cassiopeia cooperations tips and builds for a a particular rank, please select one from the selection menu provided above. If viewing for the first time, the stats and guides given are computed using all rounds with data with both champions.