You can set her passive to use hotkeys in the options menu. The default is Shift+F1~F5
Try to use Inherent Glamour sparingly, ineffective uses will put enemies on the alert.
Don't go in first to a large teamfight. Wait for your teammates to initiate.
Tumble has many uses, but it cannot pass over walls.
Condemn can be used to both pin targets to walls to ensure a kill, or to escape a pursuer.
The Neeko Vayne synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Vayne, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Neeko sees a large worsening in her KDA (ratio of kills and assists to deaths) when paired with Vayne. His KDA went down from NaN to NaN. This drop shows that Vayne helps Neeko perform worse in competitive LoL matches. Yet, the small difference proves that this performance change is not very impactful.
When Neeko tries to synergize with Vayne, she gets a little increase in her total damage dealt. This change could signal that Vayne provides protection for her to deal more damage or that her presence on the team also helps increase the match's duration. Similarly, when Neeko is played with Vayne on the same team, he usually scores many fewer killing sprees than when she plays alone. This is contrasting evidence that she is worse when playing synergisticly with Vayne.
Moreover, when Neeko plays with Vayne on the same team, she on average receives a little less damage than when she fights alone. Receiving not as much damage could mean that Vayne does a decent job of protecting Neeko during team fights.
There is no one best ally for Neeko that will no matter what be her #1 teammate. Yet, Vayne is a very typical ally for Neeko. By being on the same side as Neeko, she raises their win rate by 0.9% to 50.3%. This shows that there is only a small strategic relationship between Neeko and Vayne that allows them to perform at the top of their game together than alone.
Vayne has a greater difficulty than Neeko. That means Neeko players should be cautious when finding Vayne comrades to go into battle on the same side as, as they will require a greater level of skill to work well with you.
Working on the same side, you should observe an overall large increase in your team’s capacity to dish out massive AD. Together, these champs can tear through the other team with a lot of physcial damage.
Conversely, by bringing Neeko and Vayne together, you probably will not be giving your other teammates a lot of protection for burst damage. Make sure to pick other champions on your team that nullifies this disparity in this pairing's capabilities.
Regardless of the ability of your Vayne ally, you should focus on increasing your gold income, staying alive by avoiding foolish fights, and taking down objectives. If you do this, you will do well anyway.
To truly master Neeko to work well with Vayne during both the early game and mid / late game phases of League, you should keep reading to gather a few extra tricks and insights into this champion pairing. If you listen to the build and tips presented here, you should grow your win rate significantly.
The best items to get in your Neeko and Vayne synergy build include Cryptbloom, Hextech Rocketbelt, and Stormsurge. When Neeko combined at least these three great items in her build, she performed significantly better as an ally of Vayne than with most other typical item sets. In fact, Neeko had an average winrate of 50.3% when playing alongside Vayne with this build.
To have the greatest chance of defeating your oponents, Neeko players should equip the Electrocute, Taste of Blood, Eyeball Collection, Treasure Hunter, Manaflow Band, and Scorch runes from the Domination and Sorcery rune sets. Out of all the rune combinations that we analyzed for this team composition, this composite of runes resulted in the best win rate. Moreover, these runes averaged a 50.3% winrate overall.
If you want to view Neeko and Vayne synergy tips and stats for a a distinct skill level, please choose one from the selection menu above. At first, the stats and build suggestions displayed are computed using all matches run with both champs.