You can set her passive to use hotkeys in the options menu. The default is Shift+F1~F5
Try to use Inherent Glamour sparingly, ineffective uses will put enemies on the alert.
Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
The Neeko Karthus synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Karthus, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Neeko sees a very large drop in her KDA (ratio of kills and assists to deaths) when paired with Karthus. His KDA worsened from NaN to NaN. This worsening shows that Karthus helps Neeko perform not as well in ranked League of Legends games. Yet, the small difference shows that this performance change is not very impactful.
When Neeko tries to synergize with Karthus, she sees a little decrease in her full damage output. This could signal that Karthus does not support by providing cover for her to deal more damage or that his support also helps extend the round's duration. Similarly, when Neeko is played alongside Karthus on the same side, he usually scores many fewer killing sprees than when she plays on his own. This is contrasting evidence that she is worse when playing synergisticly with Karthus.
Moreover, when Neeko plays with Karthus on the same team, she usually takes a little more damage than when she plays alone. Getting dealt more damage may indicate that Karthus does a poor job of covering Neeko in team fights.
There is no one best synergy for Neeko that will always be her ideal synergy. However, overall, Karthus is a below average companion for Neeko. By being on the same team as Neeko, he drops their win rate by -2.9% to 46.5%. This clearly indicates that there is a bad strategic relationship between Neeko and Karthus that allows them to perform not as well together than without each other.
Karthus has a greater difficulty than Neeko. That means Neeko players must be cautious when arranging Karthus allies to fight alongside, as they will require a greater level of skill to cooperate well with you.
Fighting together, Neeko players should see an overall large increase in your team’s capacity to deal magic damage. When paired, these champions can deal quite a lot of AP type damage.
Although, by grouping Neeko and Karthus together, you probably will not be granting your other allies a great deal of anti-tank damage dealing potential. We recommend you have other champions on your team that neutralizes this relative hole in this pairing's potential.
Regardless of the ability of your Karthus teammate, you should focus on maximizing your gold income, outlasting your enemies, and clearing objectives. If you follow these simple suggestions, you will do well, regardless.
If you would like to truly master Neeko in order to pair well with Karthus during both the lane and mid / late game phases of League rounds, you should keep reading to pick up a few extra lessons on this champion pairing. If you pay attention to the build and stats shown here, you will increase your win rate significantly.
The best items to have in your Neeko and Karthus synergy build include Hextech Rocketbelt, Shadowflame, and Stormsurge. When Neeko used at least these three pieces in her build, she performed significantly better as an ally of Karthus than with most other typical item sets. In fact, Neeko had an average winrate of 46.5% when playing alongside Karthus with these items in her kit.
To have the highest chance of defeating your oponents, you should use the Arcane Comet, Manaflow Band, Transcendence, Scorch, Biscuit Delivery, and Cosmic Insight runes from the Sorcery and Inspiration rune sets. Out of all the runes players used for this team composition, this order of runes yielded the greatest win rate. Moreover, these runes averaged a 46.5% win rate overall.
If you want to view Neeko with Karthus cooperations tips and stats for a a distinct rank, feel free to select one from the selection menu displayed above. If viewing for the first time, the statistics and strategies shown are computed using all games completed with these champs.