You can set her passive to use hotkeys in the options menu. The default is Shift+F1~F5
Try to use Inherent Glamour sparingly, ineffective uses will put enemies on the alert.
Make sure to buy items that will evolve at least 1 or 2 of your spells.
Work with your teammates to set up your Ultimate and optimize damage with your passive.
Try to catch enemy carries alone to burst them with Icathian Rain.
The Neeko Kai'Sa synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Kai'Sa, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Neeko sees a large worsening in her KDA (ratio of kills and assists to deaths) when paired with Kai'Sa. His KDA fell from NaN to NaN. This worsening shows that Kai'Sa helps Neeko perform poorer in ranked LoL rounds. Yet, the small difference demonstrates that this performance change is not very impactful.
When Neeko is an ally to Kai'Sa, she observes a small increase in her full damage dealt. This change could demonstrate that Kai'Sa provides cover for her to dish out more damage or that her allyship also helps increase the game's duration. Similarly, when Neeko is played together with Kai'Sa on the same side, he usually scores many fewer killing sprees compared to when she plays alone. This is contrasting evidence that she is worse when playing synergisticly with Kai'Sa.
Moreover, when Neeko plays with Kai'Sa on the same team, she on average takes a little more damage than when she plays alone. Receiving more damage could indicate that Kai'Sa does a poor job of protecting Neeko during team fights.
There is no one best ally for Neeko that will 100% of the time be her top synergy. However, overall, Kai'Sa is a very bad companion for Neeko. By locking into the same side as Neeko, she lowers their win rate by -3.2% to 46.2%. This signals that there is an easy to overcome and exploit bond between Neeko and Kai'Sa that results in them performing not as well together than without each other.
Kai'Sa has a greater difficulty than Neeko. That means Neeko players need to be careful when finding Kai'Sa teammates to play with, as they will require a greater level of skill to be able to work well with you.
When playing cooperatively, Neeko players will likely observe an overall large increase in your team’s capability to to do a lot of AP damage. When paired, these champions can blast through enemies with magic damage.
Conversely, by aligning Neeko and Kai'Sa together, you may not be giving your side very much support. Make sure to have other champions on your team that fills this hole in this pairing's playstyle.
Regardless of your Kai'Sa ally's ability, you need to focus on increasing your gold income, warding to avoid ambushes, and taking down objectives. If you follow these simple suggestions, you should do well, regardless.
To truly master Neeko in order to pair well with Kai'Sa during both the laning and mid / late game phases of LoL games, you should keep reading to learn some more lessons on this champion pairing. If you use the build and stats shown above, you will increase your win rate by a lot.
The ideal finished items to get in your Neeko and Kai'Sa synergy build consist of Cryptbloom, Hextech Rocketbelt, and Zhonya's Hourglass. When Neeko used at least these three pieces in her build, she performed a lot better when fighting alongside Kai'Sa than with many other commonly used item sets. In fact, Neeko had an average win rate of 46.2% when synergizing her build and playstyle to Kai'Sa with this build.
To have the highest probability of annihilating your oponents, Neeko players should take the Electrocute, Taste of Blood, Eyeball Collection, Treasure Hunter, Manaflow Band, and Scorch runes from the Domination and Sorcery rune sets. Of all the runes players chose for Neeko and Kai'Sa pairings, this set of runes resulted in the top win rate. Moreover, these runes averaged a 46.2% winrate overall.
If you would like to see Neeko and Kai'Sa synergy tips and stats for a a specific division, feel free to choose one from the selection menu displayed above. By default, the statistics and guides shown are calculated using every round played with these champions.