You can set her passive to use hotkeys in the options menu. The default is Shift+F1~F5
Try to use Inherent Glamour sparingly, ineffective uses will put enemies on the alert.
Lead your enemy when targeting with Noxious Blast to ensure the hit.
Use Twin Fang on poisoned stationary targets like monsters and units stunned by her Petrifying Gaze for maximum damage.
The Neeko Cassiopeia synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Cassiopeia, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Neeko sees a large worsening in her KDA (ratio of kills and assists to deaths) when paired with Cassiopeia. His KDA went down from NaN to NaN. This decrease shows that Cassiopeia helps Neeko perform poorer in competitive LoL games. Yet, the small difference indicates that this performance change is not very impactful.
When Neeko is an ally to Cassiopeia, she sees a barely noticable drop in her total damage dealt. This difference could indicate that Cassiopeia doesn't help cover for her to dish out more damage or that her presence on the team also helps extend the round's duration. Similarly, when Neeko is played with Cassiopeia on the same side, he usually scores many fewer killing sprees compared to when she plays alone. This is contrasting evidence that she is worse when playing synergisticly with Cassiopeia.
Moreover, when Neeko plays with Cassiopeia on the same team, she on average takes a little more damage than when she fights alone. Receiving more damage may indicate that Cassiopeia does a poor job of covering Neeko in team fights.
There is no ideal ally for Neeko that will 100% of the time be her top synergy. Yet, overall, Cassiopeia is a very typical companion for Neeko. By being on the same side as Neeko, she drops their win rate by -0.5% to 48.9%. This clearly indicates that there is not really a strong bond between Neeko and Cassiopeia that results in them performing not as well together than alone.
Cassiopeia has a much greater difficulty compared to Neeko. That means Neeko players must be careful when enlisting Cassiopeia teammates to fight alongside, as they will require a much greater level of skill to work well with you.
Playing on the same side, Neeko players should expect to observe an overall large increase in your team’s capacity to to do a lot of AP damage. Together, these champs are able to dish out a surprising amount of magic type damage.
In contrast, by pairing Neeko and Cassiopeia together, you may not be giving your other allies a great deal of attack damage. Make sure to bring other champions on your team that offsets this hole in this pairing's abilities.
Regardless of the skill of your Cassiopeia ally, you should focus on increasing your income, staying alive by avoiding foolish fights, and taking down objectives. If you do this, you should do well, regardless.
To truly master Neeko in order to synergize with Cassiopeia during both the early game and mid / late game phases of LoL matches, you should continue reading to pick up additional tips and tricks for this champion pairing. If you mind the build and suggestions displayed here, you will grow your win rate by a lot.
The most crucial items to build first in your Neeko and Cassiopeia synergy build include Hextech Rocketbelt, Zhonya's Hourglass, and Zaz'Zak's Realmspike. When Neeko used at least these three pieces in her build, she did significantly better when fighting alongside Cassiopeia than with many other common item sets. In fact, Neeko had an average win rate of 48.9% when playing alongside Cassiopeia with these items in her kit.
To have the greatest probability of coming out on top against your oponents, you should use the Arcane Comet, Manaflow Band, Transcendence, Scorch, Biscuit Delivery, and Cosmic Insight runes from the Sorcery and Inspiration rune sets. Out of all the rune combinations players chose for this champion pairing, this blending of runes resulted in the top win rate. Moreover, these runes averaged a 48.9% win rate overall.
By default, tips, stats, and builds on how to synergize Cassiopeia with Neeko are given for all skill levels combined. If you would like to scope the statistics and builds to a distinct skill level, you can use the selection menu earlier in the counter matchup guide.