You can set her passive to use hotkeys in the options menu. The default is Shift+F1~F5
Try to use Inherent Glamour sparingly, ineffective uses will put enemies on the alert.
Molten Shield is a good spell to cast to work up to Annie's stun, so sometimes it's beneficial to grab at least 1 rank in it early.
Striking killing blows on minions with Disintegrate enables Annie to farm extremely well early in the game.
Storing a stun for use with her ultimate can turn the tide of a team fight.
The Neeko Annie synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Annie, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Neeko sees a large worsening in her KDA (ratio of kills and assists to deaths) when paired with Annie. His KDA worsened from NaN to NaN. This drop shows that Annie helps Neeko perform not as well in ranked League matches. Yet, the small difference proves that this performance change is only marginal.
When Neeko tries to synergize with Annie, she sees a barely noticable drop in her complete damage output. This change could demonstrate that Annie does not help protection for her to dish out more damage or that her presence on the team also helps extend the round's duration. Similarly, when Neeko is played alongside Annie on the same team, he usually scores many fewer killing sprees than when she plays without Annie. This is contrasting evidence that she is worse when playing synergisticly with Annie.
Moreover, when Neeko plays with Annie on the same team, she usually takes a little less damage than when she fights alone. Getting dealt not as much damage may indicate that Annie does a decent job of covering Neeko during team fights.
There is no top champion pairing for Neeko that will no matter what be her best teammate. However, Annie is a not very good companion for Neeko. By playing on the same team as Neeko, she drops their win rate by -2.8% to 46.6%. This signals that there is a bad synergy between Neeko and Annie that results in them performing not as well together than without each other.
Annie has a greater difficulty than Neeko. That means you must be cautious when finding Annie teammates to fight alongside, as they will require a greater level of skill to be able to work well with you.
Fighting on the same side, Neeko players will likely see an overall large increase in your team’s capability to to do a lot of AP damage. Combined, these two can deal quite a lot of AP type damage.
In contrast, by aligning Neeko and Annie together, you will not be giving your side a lot of AD. Make sure to include other champions on your team that helps cover this relative hole in their playstyle.
Regardless of the ability of your Annie ally, you need to focus on maximizing your gold income, warding to avoid ambushes, and clearing objectives. If you do this, you will do well anyway.
If you would like to truly master Neeko in order to synergize with Annie during both the early game and mid / late game phases of League matches, you should keep reading to master a few extra tricks and insights into this champion pairing. If you listen to the build and stats presented here, you will increase your win rate significantly.
The best finished items to focus on in your Neeko and Annie synergy build consist of Hextech Rocketbelt, Zhonya's Hourglass, and Zaz'Zak's Realmspike. When Neeko combined at least these three finished items in her build, she performed a lot better when paired up with Annie than with many other common item sets. In fact, Neeko had an average win rate of 46.6% helping carry Annie with these items in her kit.
To have the highest probability of crushing your oponents, Neeko players should equip the Arcane Comet, Manaflow Band, Transcendence, Scorch, Biscuit Delivery, and Cosmic Insight runes from the Sorcery and Inspiration rune sets. Of all the rune combinations that we analyzed for Neeko and Annie pairings, this order of runes yielded the highest win rate. Moreover, these runes averaged a 46.6% winrate overall.
If you would like to view Neeko with Annie cooperations tips and builds for a an individual player tier, feel free to choose one from the selection menu provided above. By default, the stats and build suggestions shown are computed using every match completed with these champs.