Lissandra's abilities are shorter range than those of many mages. As a result, buying items that offer both ability power and defense, like Zhonya's Hourglass and Banshee's Veil, can be a great choice to help her both survive and deal damage.
Casting Glacial Path and then running in the opposite direction will leave your enemies uncertain which way you will actually go.
You can instantly use your ultimate on yourself by pressing the self cast key and the ultimate key at once (alt+R by default).
Don't go in first to a large teamfight. Wait for your teammates to initiate.
Tumble has many uses, but it cannot pass over walls.
Condemn can be used to both pin targets to walls to ensure a kill, or to escape a pursuer.
The Lissandra Vayne synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Vayne, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Lissandra sees a very large drop in her KDA (ratio of kills and assists to deaths) when paired with Vayne. His KDA fell from NaN to NaN. This decrease shows that Vayne helps Lissandra perform worse in competitive League matches. Yet, the small difference demonstrates that this performance change is only marginal.
When Lissandra tries to synergize with Vayne, she gets a little decrease in her total damage dealt. This could indicate that Vayne doesn't help protection for her to deal more damage or that her support also helps extend the match's duration. Similarly, when Lissandra is played together with Vayne on the same side, he usually scores many fewer killing sprees than when she plays without Vayne. This is contrasting evidence that she is worse when playing synergisticly with Vayne.
Additionally, when Lissandra plays with Vayne on the same side, she usually receives a little less damage than when she plays alone. Getting dealt not as much damage could mean that Vayne does a decent job of protecting Lissandra in team fights.
There is no universally accepted best synergy for Lissandra that will always be her #1 ally. Yet, overall, Vayne is a very typical teammate for Lissandra. By locking into the same side as Lissandra, she lowers their win rate by -0.1% to 49.4%. This demonstrates that there is a weak bond between Lissandra and Vayne that allows them to perform worse together than alone.
Vayne has a greater difficulty than Lissandra. That means Lissandra players should be very careful when enlisting Vayne teammates to play with, as they will have to have a greater level of skill to be able to fight well with you.
Working cooperatively, you will likely see an overall large increase in your team’s ability to deal physical damage. Combined, these two should be able to take down targets with auto-attacks and other AD damage abilities.
Conversely, by aligning Lissandra and Vayne together, you will not be giving your side enough tankyness. We recommend you pick other champs on your team that nullifies this relative disparity in this pairing's kit.
Regardless of your Vayne ally's ability, you should focus on increasing your income, outlasting your enemies, and clearing objectives. If you follow these simple suggestions, you will do well, regardless.
If you would like to truly master Lissandra in order to synergize with Vayne during both the lane and mid / late game phases of League rounds, you should continue reading to gather a few extra lessons on this champion pairing. If you use the build and tips presented above, you will grow your win rate significantly.
The top items to have in your Lissandra and Vayne synergy build consist of Rabadon's Deathcap, Malignance, and Shadowflame. When Lissandra combined at least these three great items in her build, she did a lot better when fighting alongside Vayne than with most other typical builds. In fact, Lissandra had an average win rate of 49.4% helping carry Vayne with this build.
To have the highest likelihood of beating your oponents, Lissandra players should use the Electrocute, Cheap Shot, Eyeball Collection, Ultimate Hunter, Manaflow Band, and Transcendence runes from the Domination and Sorcery rune sets. Of all the rune combinations players used for this champion pairing, this set of runes resulted in the best win rate. Moreover, these runes provided a 49.4% winrate overall.
If you would like to get Lissandra and Vayne collaboration tips and builds for a a specific skill level, feel free to choose one from the selection menu provided above. By default, the statistics and build suggestions shown are computed using every match completed with both champions.