Lissandra's abilities are shorter range than those of many mages. As a result, buying items that offer both ability power and defense, like Zhonya's Hourglass and Banshee's Veil, can be a great choice to help her both survive and deal damage.
Casting Glacial Path and then running in the opposite direction will leave your enemies uncertain which way you will actually go.
You can instantly use your ultimate on yourself by pressing the self cast key and the ultimate key at once (alt+R by default).
Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
The Lissandra Karthus synergy stats shown here demonstrate the areas of her gameplay that do better (or worse) when paired with Karthus, compared to her overall stats. Significant differences are areas of focus that highlight how her gameplay changes when paired with this other champion.
Overall, Lissandra sees a very large drop in her KDA (ratio of kills and assists to deaths) when paired with Karthus. His KDA decreased from NaN to NaN. This worsening shows that Karthus helps Lissandra perform worse in ranked League rounds. Yet, the small difference proves that this performance change is not very impactful.
When Lissandra is an ally to Karthus, she observes a barely noticable drop in her full damage output. This difference may indicate that Karthus does not support by providing protection for her to deal more damage or that his presence also helps extend the match's duration. Similarly, when Lissandra is played alongside Karthus on the same team, he usually scores many fewer killing sprees compared to when she plays alone. This is contrasting evidence that she is worse when playing synergisticly with Karthus.
Additionally, when Lissandra plays with Karthus on the same team, she usually receives more damage than when she fights alone. Getting dealt more damage may mean that Karthus does a poor job of protecting Lissandra in teamfights.
There is no one best companion for Lissandra that will always be her ideal ally. However, overall, Karthus is a very bad ally for Lissandra. By being on the same side as Lissandra, he decreases their win rate by -6.9% to 42.6%. This signals that there is a very bad bond between Lissandra and Karthus that results in them performing not as well together than without each other.
Karthus has a greater difficulty than Lissandra. That means you must be very careful when lining up Karthus teammates to go into battle on the same side as, as they will require a greater level of skill to work well with you.
Fighting alongside, Lissandra players should observe an overall large increase in your team’s capability to deal magical damage. Together, these champions can deal quite a lot of AP type damage.
Conversely, by grouping Lissandra and Karthus together, you probably will not be providing your side a lot of sustained damage output. Make sure to pick other champions on your team that helps cover this relative disparity in this pairing's potential.
Regardless of the skill of your Karthus ally, you should focus on maximizing your income, staying alive by avoiding foolish fights, and clearing objectives. If you heed this simple advice, you will do well, regardless.
If you would like to truly master Lissandra to work well with Karthus during both the lane and mid / late game phases of LoL games, you should keep reading to master some more lessons on this champion pairing. If you pay attention to the build and suggestions shown above, you will grow your win rate by a lot.
The ideal finished items to focus on in your Lissandra and Karthus synergy build consist of Malignance, Zhonya's Hourglass, and Shadowflame. When Lissandra bought at least these three finished items in her build, she performed significantly better as an ally of Karthus than with many other common item sets. In fact, Lissandra had an average winrate of 42.6% helping carry Karthus with these items in her kit.
To have the highest probability of coming out on top against your oponents, Lissandra players should take the Electrocute, Cheap Shot, Eyeball Collection, Ultimate Hunter, Manaflow Band, and Transcendence runes from the Domination and Sorcery rune sets. Out of all the rune combinations we have analyed for Lissandra and Karthus pairings, this combination of runes yielded the best win rate. In fact, these runes averaged a 42.6% winrate overall.
If you need to see Lissandra with Karthus synergy tips and builds for a a distinct skill level, feel free to select one from the selection menu displayed above. If viewing for the first time, the stats and strategies displayed are calculated using all games with data with these champs.