Take advantage of Flurry by weaving in basic attacks between spell casts - this maximizes damage output and minimizes Energy loss.
Use Sonic Wave before Dragon's Rage so you can chase the target with Resonating Strike.
Self-casting Safeguard and using Iron Will are powerful tools for killing neutral monsters (in the jungle).
Lay Waste is very strong at farming minions and harassing enemy champions.
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
The K'Sante Karthus synergy stats shown here demonstrate the areas of their gameplay that do better (or worse) when paired with Karthus, compared to their overall stats. Significant differences are areas of focus that highlight how their gameplay changes when paired with this other champion.
Overall, K'Sante sees a very large drop in their KDA (ratio of kills and assists to deaths) when paired with Karthus. His KDA went down from NaN to NaN. This negative change shows that Karthus helps K'Sante perform not as well in ranked League of Legends games. Yet, the small difference shows that this performance change is not very impactful.
When K'Sante tries to synergize with Karthus, they gets a little increase in their full damage output. This may indicate that Karthus helps provide cover for them to deal more damage or that his support also helps extend the match's duration. Similarly, when K'Sante is played alongside Karthus on the same side, he usually scores many fewer killing sprees compared to when they plays on his own. This is contrasting evidence that they is worse when playing with Karthus.
Additionally, when K'Sante plays with Karthus on the same team, they often receives more damage than when they fights alone. Getting dealt more damage could indicate that Karthus does a poor job of protecting K'Sante in teamfights.
There is no perfect champion pairing for K'Sante that will 100% of the time be their ideal teammate. Yet, overall, Karthus is a relatively poor companion for K'Sante. By locking into the same team as K'Sante, he lowers their win rate by -2.9% to 44.3%. This demonstrates that there is a bad bond between K'Sante and Karthus that results in them performing not as well together than alone.
Karthus has a lower difficulty than K'Sante. That means you don't need to be very careful when finding Karthus comrades to fight alongside, as they will need a lower level of skill to be able to do well with you.
Playing together, K'Sante players will likely witness an overall large increase in your team’s capacity to deal magical damage. Combined, these two are able to dish out a surprising amount of magic type damage.
In contrast, by bringing K'Sante and Karthus together, you will not be granting your other teammates much utility. Plan to pick other champions on your team that neutralizes this relative hole in their capabilities.
Regardless of your Karthus ally's skill level, you need to focus on increasing your income, warding to avoid ambushes, and clearing objectives. If you do this, you should do well, regardless.
If you would like to truly master K'Sante to pair well with Karthus during both the early game and mid / late game phases of League of Legends games, you should continue reading to learn additional lessons on this champion pairing. If you pay attention to the build and suggestions presented here, you should increase your win rate by a lot.
The most important finished items to prioritize in your K'Sante and Karthus synergy build consist of Thornmail, Iceborn Gauntlet, and Jak'Sho, The Protean. When K'Sante included at least these three pieces in their build, they did a lot better when paired up with Karthus than with many other common builds. In fact, K'Sante boasted an average win rate of 44.3% helping carry Karthus with this build.
To have the highest probability of defeating your oponents, you should use the Grasp of the Undying, Demolish, Conditioning, Overgrowth, Approach Velocity, and Biscuit Delivery runes from the Resolve and Inspiration rune sets. Out of all the rune builds players picked for K'Sante and Karthus pairings, this combo of runes yielded the top win rate. In fact, these runes averaged a 44.3% winrate overall.
By default, tips, stats, and builds on how to team up Karthus with K'Sante are shown for every ranked division. If you want to narrow the stats and builds to a specific player tier, you may use the selection menu located earlier on the page.