Kassadin's ultimate has many uses and is on a shorter cooldown than most, use it often.
Kassadin has multiple item paths; he can go caster via Mana and Ability Power or anti-caster with Cooldown Reduction and Magic Resist.
Try to get the Ancient Golem buff to counteract Riftwalk's increasing Mana cost.
The Kassadin Senna synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Senna, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Kassadin sees a very large drop in his KDA (ratio of kills and assists to deaths) when paired with Senna. His KDA decreased from NaN to NaN. This decrease shows that Senna helps Kassadin perform worse in ranked League matches. Yet, the small difference shows that this performance change is only marginal.
When Kassadin is paired with Senna, he observes a little decrease in his total damage output. This difference could signal that Senna does not provide cover for him to deal more damage or that her support also helps increase the match's duration. Similarly, when Kassadin is played with Senna on the same team, he usually scores many fewer killing sprees than when he plays alone. This is contrasting evidence that he is worse when playing with Senna.
Moreover, when Kassadin plays with Senna on the same team, he on average takes a little less damage than when he fights alone. Getting dealt not as much damage may indicate that Senna does a decent job of protecting Kassadin in team fights.
There is no ideal synergy for Kassadin that will always be his top teammate. However, overall, Senna is a very typical ally for Kassadin. By locking into the same side as Kassadin, she has no effect on their win rate by 0.0% to 50.0%. This clearly indicates that there is only a small strategic relationship between Kassadin and Senna that results in them performing at the same level together than alone.
Senna has a lower difficulty than Kassadin. That means Kassadin players don't need to be cautious when finding Senna teammates to fight alongside, as they will have to have a relatively low level of skill to play well with you.
Fighting cooperatively, Kassadin players should observe an overall large increase in your team’s capacity to to do a lot of AP damage. When paired, these champs can blast through enemies with magic damage.
In contrast, by bringing Kassadin and Senna together, you probably will not be giving your other allies a lot of tankyness. Plan to have other champions on your team that neutralizes this relative gap in this pairing's potential.
Regardless of the skill of your Senna teammate, you need to focus on increasing your income, outlasting your enemies, and clearing objectives. If you do this, you should do well, regardless.
To truly master Kassadin in order to work well with Senna during both the laning and mid / late game phases of League, you should continue reading to learn some more tricks and insights into this champion pairing. If you mind the build and stats shown above, you will increase your win rate by a lot.
The best finished items to build first in your Kassadin and Senna synergy build include Seraph's Embrace, Rabadon's Deathcap, and Void Staff. When Kassadin combined at least these three great items in his build, he did much better when paired up with Senna than with most other typical builds. In fact, Kassadin boasted an average winrate of 50.0% when synergizing his build and playstyle to Senna with these items in his kit.
To have the greatest chance of coming out on top against your oponents, you should equip the First Strike, Magical Footwear, Future's Market, Cosmic Insight, Sudden Impact, and Ultimate Hunter runes from the Inspiration and Domination rune sets. Out of all the rune combinations players used for this team composition, this mixture of runes yielded the highest win rate. Notably, these runes averaged a 50.0% win rate overall.
If you need to see Kassadin and Senna synergy tips and stats for a a distinct division, please choose one from the selection menu provided above. At first, the statistics and build suggestions given are computed using all matches completed with both champs.