Kassadin's ultimate has many uses and is on a shorter cooldown than most, use it often.
Kassadin has multiple item paths; he can go caster via Mana and Ability Power or anti-caster with Cooldown Reduction and Magic Resist.
Try to get the Ancient Golem buff to counteract Riftwalk's increasing Mana cost.
Make sure to buy items that will evolve at least 1 or 2 of your spells.
Work with your teammates to set up your Ultimate and optimize damage with your passive.
Try to catch enemy carries alone to burst them with Icathian Rain.
The Kassadin Kai'Sa synergy stats shown here demonstrate the areas of his gameplay that do better (or worse) when paired with Kai'Sa, compared to his overall stats. Significant differences are areas of focus that highlight how his gameplay changes when paired with this other champion.
Overall, Kassadin sees a large worsening in his KDA (ratio of kills and assists to deaths) when paired with Kai'Sa. His KDA decreased from NaN to NaN. This worsening shows that Kai'Sa helps Kassadin perform not as well in ranked League of Legends games. Yet, the small difference indicates that this performance change is only marginal.
When Kassadin is paired with Kai'Sa, he gets a little decrease in his complete damage dealt. This difference could demonstrate that Kai'Sa does not help cover for him to deal more damage or that her allyship also helps extend the round's duration. Similarly, when Kassadin is played alongside Kai'Sa on the same side, he usually scores many fewer killing sprees compared to when he plays alone. This is contrasting evidence that he is worse when playing with Kai'Sa.
Additionally, when Kassadin plays with Kai'Sa on the same team, he usually takes a little less damage than when he fights alone. Taking not as much damage may mean that Kai'Sa does a decent job of protecting Kassadin in teamfights.
There is no ideal companion for Kassadin that will always be his top teammate. However, overall, Kai'Sa is a terrible teammate for Kassadin. By playing on the same side as Kassadin, she decreases their win rate by -5.1% to 44.9%. This demonstrates that there is a terrible bond between Kassadin and Kai'Sa that results in them performing not as well together than without each other.
Kai'Sa has a lower difficulty than Kassadin. That means you don't need to be careful when arranging Kai'Sa teammates to go into battle on the same side as, as they will need a lower level of skill to work well with you.
When playing on the same side, Kassadin players should expect to see an overall large increase in your team’s capability to deal physical damage. Together, these two can provide a great amount of sustained physical damage.
Although, by pairing Kassadin and Kai'Sa together, you probably will not be granting your team very much utility. Make sure to include other champions on your team that fills this gap in their playstyle.
Regardless of your Kai'Sa ally's skill level, you should focus on increasing your gold income, warding to avoid ambushes, and taking down objectives. If you heed this simple advice, you should do well anyway.
If you would like to learn all of the intricacies of Kassadin to synergize with Kai'Sa during both the early game and mid / late game phases of LoL rounds, you should keep reading to gather additional lessons on this champion pairing. If you mind the build and stats displayed here, you will grow your win rate by a lot.
The ideal items to include in your Kassadin and Kai'Sa synergy build include Seraph's Embrace, Rabadon's Deathcap, and Malignance. When Kassadin used at least these three great items in his build, he performed much better when paired up with Kai'Sa than with many other typical item sets. In fact, Kassadin boasted an average winrate of 44.9% when synergizing his build and playstyle to Kai'Sa with these items in his kit.
To have the greatest likelihood of coming out on top against your oponents, Kassadin players should take the First Strike, Magical Footwear, Future's Market, Cosmic Insight, Sudden Impact, and Ultimate Hunter runes from the Inspiration and Domination rune sets. Of all the rune combinations we have analyed for this team composition, this combo of runes yielded the best win rate. In fact, these runes gave a 44.9% winrate overall.
If you would like to view Kassadin with Kai'Sa cooperations tips and stats for a a particular skill level, please choose one from the selection menu above. If viewing for the first time, the statistics and tips and suggestions shown are computed using every round with data with both champions.